18 - Immunologic Disorders

• IgE mediated
• Occurs when antigen makes contact with body, and binds to receptors on mast cells and basophiles
• Characterized by immediate reaction of individual
• Inherited
• Can be local anaphylaxis - one spot, or generalized anaphylaxis - whole body

Name given for IgE mediated allergic reactions

• Hives - wheal and flare rash
• Hay fever - teary eyes, sneezing, runny nose
• Asthma - inflamed respiratory tract

• Antigen enters blood stream and becomes wide spread
• May induce shock

Technique used to modify immune system by injecting individual with extremely diluted suspension of allergen

• Delayed hypersensitivities caused by cell mediated immunity.
• T-Cells are responsible
• Body slowly develops a response to antigen
• Responsible for contact dermatitis, rejection of tissue grafts, some autoimmune diseases.
• TB test

T-Cells release cytokines, which initiate inflammation, which attracts macrophages

• Poison Ivy/Oak
• Nickel in metal jewelry
• Chromium salts in leather
• Latex products

A disease that causes the body to attacks its own tissues