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HLA-A, HLA-B, HLA-C.
MHC I
-
-
Expressed on all nucleated cells. Not expressed on RBC.
MHC I
-
Antigen is loaded in RER with mostly intracellular peptides.
MHC I
-
Mediates viral immunity.
MHC I
-
Pairs with Beta2-microglobulin (aids in transport to cell surface).
MHC I
-
HLA-DR, HLA-DP, HLA-DQ.
M HC II
-
Binds TCR and CD4.
M HC II
-
Expressed only on antigen-presenting cells (APCs).
M HC II
-
Antigen is loaded following release of invariant chain in an acidified endosome.
M HC II
-
-
B27
- Psoriasis
- Ankylosing spondylitis, Inflammatory PAIR.
- bowel disease, Reiter's syndrome.
-
-
DR2
- Multiple sclerosis, hay fever, SLE,
- Goodpasture's.
-
DR3
Diabetes mellitus type l, Graves' disease.
-
DR4
Rheumatoid arthritis, diabetes mellitus type l.
-
DR5
- Pernicious anemia -+ B12 deficiency,
- Hashimoto's thyroiditis
-
-
Ankylosing spondylitis
B27
-
Inflammatory bowel disease
B27
-
-
-
-
-
-
-
Diabetes mellitus type l,
DR3, DR4
-
-
-
-
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