What is the cytoskeleton and what is its' importance in the cell?
Composed of a network of proteins and tubules within the cell cytoplasm: 1. Actin filaments (microfilaments) 2. Microtubules and 3. Intermediate filaments
Importance: movement of proein from ER to Golgi via microtubules, intercellular motility, role in cell division, protein structure and shape
What types of cellular/intracellular motility are dependent on the actin (microfilament) cytoskeleton?
Cell motility, assembly and disassembly in the following:
1. Brush border of epithelial cells: surface expansion
2. epidermis of plants: to allow cytoplasmic flow
3. RBC membrane: form a structural matrix network for stability
4. Bacteria: DNA molecule segregation and cell shape maintenance
5. Slime mold (Physarum): cytoplasmic streaming
What types of cellular/intracellular motility are dependent on the microtubule (MT) cytoskeleton?
1.Cell shape & Maintenance
2.Intracellular transport: dyneins and kinesins which transport vesicles ie:mitochondria
3.Cell wall synthesis in plants
4.Mitotic spindle creation
5.Axoneme in cilia and flagella
What roles do microfilaments (Mfs) play in cell organization/structure/function?
1. Cell motility
2. Intracellular motility
3. Cell Shape
4. Adhesion*
5. Cell-to-cell interactions*
6. Cytokinesis*
7. Cell SIGNALING
What roles do microtubules (Mts) play in cell organization/structure/function?
1. Cell motility
2. Intracellular motility
3. Cell Shape
4. Organization of cytoplasm*
5. Karyokinesis*
6. Cell SIGNALING
What roles do intermediate filaments (Ifs) play in cell organization/structure/function?
1. Cell and Tissue structure and integrity (and nuclear structure and integrity)