Pappenheimer bodies - blue/purple in color, in periphery, and not perfectly round; smaller than Howell-Jolly bodies; expelled iron-containing mitochondria
All of the following can show extensive replacement of BM by fibrous/spindled processes except:
A) Hodgkin lymphoma
C) Hairy cell leukemia
D) AML M4
D - only AML M7 (megakaryoblastic)
What are potential causes of serous fat atrophy (gelatinous transformation)?
Mnemonic: MaDAM anorexic
Malnutrition - anorexia
What is the average MPV for a platelet? What is the relationship between platelet volume (MPV) and platelet count? When does MPV go down? Up?
Between 2fL and 20fL; inverse relationship; down with thrombocytopenia or impaired production (AA); up with destruction, ITP, MPN, Bernard Soulier, etc. (basically getting bigger immature plts pushed out)
a 36 year old female presented with fever and flank pain. She was found to be pancytopenic with a WBC of 1.7, K/mm3. Absolute neutrophil count of 1.1, H/H 11.6/33.3, and plts 124 K/mm3. Diagnosis?
Parvovirus (picture shows giant proerythroblasts with nuclear inclusions)
A two-month old girl presented with cough and SOB. CBC showed leukocytosis with marked lymphocytosis. PB smear below. Dx?
Pertussis -Numerous mature lymphs with clefted nuclei
Likely PB smear findings?
(Megaloblastic anemia with sieve-like chromatin) - macrocytic anemia with hypersegmented neutrophils
Nieman Pick - vacuolated cells
Gaucher's disease - tissue paper looking
What is the defect in Autoimmune lymphoproliferative syndrome (ALPS)? Flow cytometric findings? Clinical presentation?
Defect in Fas/CD95/Apo-1 mediated apoptosis; CD4-/CD8-, CD25-, CD45RO-, CD3+, CD57+
LAD and splenomegaly in healthy child progresses to cytopenias
Sequence of abnormal lab values in iron deficiency anemia with respect to ferritin, transferrin, serum Fe, ZPP, and MCV?