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Super Antigens?
S Aureus and S Pyogenes
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ADP ribosylating A-B Toxins?
- Corynebacterium Diphtheriae, vibrio cholerae
- E. Coli, Bordetella Pertussis
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Other Toxins?
- Clostridium Perfringes
- C. Tetani
- C. botulinum
- Bacillus anthracis
- shigella
- S. pyogenes
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S. aureus?
- Super Antigen
- TSST-1 superantigen causes toxic shock syndrome,
- food poisoning as well as exfoliatin which causes scalded skin syndrome
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S. Pyogenes?
Scarlet fever-erthrogenic toxin causes toxic shock-like syndrome
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Corynebacterium Diphtheriae?
Inactivates EF-2; causes pharyngitis and "pseudomembrane" in throat
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Vibrio cholerae?
ADP ribosylation of G protein stimulates adenylyl cyclase. Increases pumping of Cl- into gut and decreases Na absorbtion. H2O moves into lumen causing rice-water diarrhea.
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E. coli?
Heat-labile toxin Adenylate cyclase. Heat-stable stimulates Guanylate cyclase. Both cause watery diarrhea. Labile like Air, Stable like Ground
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Bordatella pertusis?
Inc. cAMP by (-) G-alpha1. causes whooping cough, (-) chemokine receptor, causes lymphocytosis
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CLostridium perfringens?
alpha toxin, a lecithinase that acts as a phospholipase to cleave cell membranesand causes gas gangrene; get a dbl zone of hemolysis on blood agar.
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C. tetani?
blocks release of inhibitory neurotransmitters GABA and glycine. causes lockjaw.
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C. botulinum?
blocks realease of ACh, causes anticholinergic symptoms, CNS paralysis. spores found in canned food and honey (floppy baby)
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Bacillus anthrasis?
Edema factor, part of toxin complex, IS AN adenylate cyclase.
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Shigella?
shiga toxin cleaves host cell rRNA (inactivates 60s). also enhances cytokine release, causing HUS.
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S. pyogenes?
Streptolysin O is a hemolysin. antigen for ASO antibody, which is used in the diagnosis of rheumatic fever.
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