1. Super Antigens?
    S Aureus and S Pyogenes
  2. ADP ribosylating A-B Toxins?
    • Corynebacterium Diphtheriae, vibrio cholerae
    • E. Coli, Bordetella Pertussis
  3. Other Toxins?
    • Clostridium Perfringes
    • C. Tetani
    • C. botulinum
    • Bacillus anthracis
    • shigella
    • S. pyogenes
  4. S. aureus?
    • Super Antigen
    • TSST-1 superantigen causes toxic shock syndrome,
    • food poisoning as well as exfoliatin which causes scalded skin syndrome
  5. S. Pyogenes?
    Scarlet fever-erthrogenic toxin causes toxic shock-like syndrome
  6. Corynebacterium Diphtheriae?
    Inactivates EF-2; causes pharyngitis and "pseudomembrane" in throat
  7. Vibrio cholerae?
    ADP ribosylation of G protein stimulates adenylyl cyclase. Increases pumping of Cl- into gut and decreases Na absorbtion. H2O moves into lumen causing rice-water diarrhea.
  8. E. coli?
    Heat-labile toxin Adenylate cyclase. Heat-stable stimulates Guanylate cyclase. Both cause watery diarrhea. Labile like Air, Stable like Ground
  9. Bordatella pertusis?
    Inc. cAMP by (-) G-alpha1. causes whooping cough, (-) chemokine receptor, causes lymphocytosis
  10. CLostridium perfringens?
    alpha toxin, a lecithinase that acts as a phospholipase to cleave cell membranesand causes gas gangrene; get a dbl zone of hemolysis on blood agar.
  11. C. tetani?
    blocks release of inhibitory neurotransmitters GABA and glycine. causes lockjaw.
  12. C. botulinum?
    blocks realease of ACh, causes anticholinergic symptoms, CNS paralysis. spores found in canned food and honey (floppy baby)
  13. Bacillus anthrasis?
    Edema factor, part of toxin complex, IS AN adenylate cyclase.
  14. Shigella?
    shiga toxin cleaves host cell rRNA (inactivates 60s). also enhances cytokine release, causing HUS.
  15. S. pyogenes?
    Streptolysin O is a hemolysin. antigen for ASO antibody, which is used in the diagnosis of rheumatic fever.
Card Set