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PHM 111 Week 1
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Explain the clotting process.
Injured tissues release thromboplastin, a substance that triggers the clotting mechanism.
What is the MOA of anticoagulants?
Inhibition of performed clotting factors (Heparin)
Prevention of synthesis of normal clotting factors( Coumadin derivatives)
Therapy is focused on preventing intravascular thrombosis by decreasing blood coagulability
Anticoagulant indications
Prevention of venous thrombosis
colt suppression prior to blood transfusions
Adverse reactions of anticoagulants?
Major ADR for both types of drugs are hemorrhage
What must be monitored when using anticoagulants?
Partial Thromboplastin Time (PPT)
Measures the function of the intrinsic and common pathways that are affected by heparin.
Name the 3 specific anticoagulants?
Heparin
Low Molecular Weight Heparins
Warfarin
Explain heparin
Inhibits thrombin activity so that fibrin cannot be formed
Derived from pork and beef lungs and intestinal tissue
Dose titrated according to PTT
Antidote is protamine sulfate
Explain Low Molecular Weight Heparings
Are smaller and have lower molecular weight than heparin
Same mechanism of action as heparin
Longer half-life than heparin
Given SC
Less lab monitoring required
Fragmin & Lovenox CAN NOT be used interchangeably (unit for unit) with each other or with heparin.
Explain Warfaring
Does not affect established clots, but does prevent further extension of formed clots
Indicated for prophylaxis and treatment of deep vein thrombosis and pulmonary thromboembolism
Also used for prophylaxis of thromboembolism associated with a trial fibrillation or myocardial infraction
Dose id titrated based on target INR (International Normalized Ration)
What are the side effects of warfarin?
Crosses placenta and causes hemorrhage in fetus.
What is the antidote of warfarin?
Vitamin K
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Author
Cruzin4Life
ID
223481
Card Set
PHM 111 Week 1
Description
PHM 111 Week 1
Updated
2013-06-12T01:03:46Z
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