-
Bethanechol CLINICAL APPLICATIONS?
- Direct Cholinomimetic Agonist
- Postoperative ileus, neurogenic ileus, and
- urinary retention
-
Carbachol CLINICAL APPLICATIONS?
- Direct Cholinomimetic Agonist
- Glaucoma, pupillary contraction, and relief of
- intraocular pressure
-
Pilocarpine CLINICAL APPLICATIONS?
- Direct Cholinomimetic Agonist
- Potent stimulator of sweat, tears, and saliva
- Open-angle and closed-angle glaucoma
-
Methacholine CLINICAL APPLICATIONS?
- Direct Cholinomimetic Agonist
- Challenge test for diagnosis of asthma
-
Bethanechol ACTION?
- Direct Cholinomimetic Agonist
- Activates bowel and bladder smooth
- muscle; resistant to AChE. "Bethany, call
- (bethanechol) me, maybe, if you want to
- activate your bowels and bladder."
-
Carbachol ACTION?
- Direct Cholinomimetic Agonist
- Carbon copy of acetylcholine.
-
Pilocarpine ACTION?
- Direct Cholinomimetic Agonist
- Contracts ciliary muscle of eye (open-angle
- glaucoma), pupillary sphincter (closed-angle
- glaucoma); resistant to AChE. "You cry, drool,
- and sweat on your 'pilow.' "
-
Methacholine ACTION?
- Direct Cholinomimetic Agonist
- Stimulates muscarinic receptors in airway when
- inhaled.
-
Neostigmine CLINICAL APPLICATIONS?
- anticholinesterase
- Postoperative and neurogenic ileus and
- urinary retention, myasthenia gravis,
- reversal of neuromuscular junction blockade
- (postoperative)
-
Pyridostigmine CLINICAL APPLICATIONS?
- anticholinesterase
- Myasthenia gravis (long acting); does not
- penetrate CNS
-
Edrophonium CLINICAL APPLICATIONS?
- anticholinesterase
- Diagnosis of myasthenia gravis (extremely short
- acting)
-
Physostigmine CLINICAL APPLICATIONS?
- anticholinesterase
- Anticholinergic toxicity (crosses blood-brain
- barrier - CNS)
-
Donepezil CLINICAL APPLICATIONS?
- anticholinesterase
- Alzheimer's disease
-
Neostigmine ACTION?
- anticholinesterase
- (+) endogenous ACh.
- Neo CNS =No CNS penetration.
-
Pyridostigmine ACTION?
- anticholinesterase
- (+) endogenous ACh; (+) strength. Pyridostigmine
- gets rid of myasthenia gravis
-
Edrophonium ACTION?
- anticholinesterase
- (+) endogenous ACh.
-
Physostigmine ACTION?
- anticholinesterase
- ^ endogenous ACh. Physostigmine "phyxes"
- atropine overdose.
-
Donepezil ACTION?
- anticholinesterase
- ^ endogenous ACh.
-
Atropine, homatropine, tropicamide ORGAN SYSTEMS?
- Muscarinic antagonists
- Eye
-
Benztropine ORGAN SYSTEMS?
Muscarinic antagonist CNS
-
Scopolamine ORGAN SYSTEMS?
-
lpratropium, tiotropium ORGAN SYSTEMS?
- Muscarinic antagonist
- Respiratory
-
Oxybutynin ORGAN SYSTEMS?
- Muscarinic antagonist
- Genitourinary
-
Glycopyrrolate ORGAN SYSTEMS?
- Muscarinic antagonist
- Gastrointestinal, respiratory
-
Atropine, homatropine, tropicamide APPLICATIONS?
- Muscarinic antagonist
- Produce mydriasis and cycloplegia
-
Benztropine APPLICATIONS?
- Muscarinic antagonist
- Parkinson's disease- "Park my Benz"
-
Scopolamine APPLICATIONS?
- Muscarinic antagonist
- Motion sickness
-
lpratropium, tiotropium APPLICATIONS?
- Muscarinic antagonist
- COPD, asthma ("' pray I can breathe soon!")
-
Oxybutynin APPLICATIONS?
- Muscarinic antagonist
- Reduce urgency in mild cystitis and reduce
- bladder spasms
-
Glycopyrrolate APPLICATIONS?
- Muscarinic antagonist
- Parenteral: preoperative use to reduce airway
- secretions
- Oral: drooling, peptic ulcer
-
Atropine Action?
- pupil dilation
- decreased airway secretions
- reduced stomach acid
- decrease gut motility
- decrease bladder urgency in cystitis
- Tx for OP poisoning
-
Atropine Toxicity?
- Hot as a hare
- Dry as a bone
- Red as a beet
- Blind as a bat
- Mad as a hatter
- Jimson weed (Datura)
-
Epinephrine?
- Direct sympathomimetics
- A12, b12
- Anaphylaxis, glaucoma (open angle), asthma,
- hypotension
-
Norepinephrine?
- Direct sympathomimetics
- A12, b1
- Hypotension (but decres. renal perfusion)
-
Isoproterenol?
- Direct sympathomimetics-b12
- Torsacle de pointes (tachycardia decreases dec. QT
- interval), braclyarrhythmias (but can worsen
- ischemia)
-
Dopamine?
- Direct sympathomimetics-A12B12D1
- Shock (renal perfusion), heart failure; inotropic and chronotropic
- (high (high (medium (medium (low
-
Dobutamine?
- Direct sympathomimetics-B1
- Heart failure, cardiac stress testing; inotropic
- and chronotropic
-
Phenylephrine?
- Direct sympathomimetics-A12
- Hypotension (vasoconstrictor), ocular
- procedures (mydriatic), rhinitis (decongestant)
-
Albuterol, salmeterol, terbutaline?
- Direct sympathomimetic-B2
- Metaproterenol and albuterol for acute asthma; salmeterol for long-term asthma or COPD
- control; terbutaline to reduce premature
- uterine contractions
-
Phenoxybenzamine Use?
- Nonselective a-blocker
- Pheochromocytoma
-
Prazosin, terazosin, doxazosin, tamsulosin Use?
- a1 selective blocker (-osin ending)
- Hypertension, urinary retention in BPH
-
Mirtazapine Use?
- a2 selective blocker
- Depression
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