microbio 6.5.13

  1. virulence
    the properties of a microbe that enhance pathogenicity
  2. invasiveness factors
    • 1.the microbe's ability to replicate rapidly
    • 2.how well a microbe attaches to the host (fimbrae, spikes, glycocalyx)
    • 3.promote microbial entry
  3. keratinase
    produced by some fungi(ringworm and digest the keratin in skin)
  4. hyaluronidase
    digest hyaluronic acid, intercellular"cementing" substance btween surface cell
  5. collagenase
    digests collagen, most common protein in the body (connective tissue)
  6. streptokinase/staphlokinase
    covert plasminogen into plasmin, an enzymes that breaks down blood clot.
  7. coagulase
    web-like clot that impedes WBC movement
  8. leukocidin
    kills WBC
  9. fimbriae and capsules mechanically interfere with phagocyotsis
    microbial inhibition of phagocyotisis
  10. Toxigneicity
    toxins disrupt the cell membrane or the internal activities of a cell
  11. Endotoxins
    G-, are the lipid A part of the outer memebrane ,are relased when G- die, are weak, nonspcific and cause a fever, stimulate weak immunity, are stable( can NOt be denatured and coverted into toxoid,can NOT be used for immunization)
  12. Exotoxin
    few G+,G-, secreted, polypetide, unstable, POWERFUL, and do NOT cause fever/stimulate strong immunity, can be denatured and coverted to a toxoid which can be used for immunization, and are highly specific! Neurotoxins  &  Enterotoxins
  13. Neurotoxin
    attack the Nervous System (Botulin and tetanospasmin)
  14. Enterotoxin
    attack organs of the digestive tract (shiga and cholera toxin)
Card Set
microbio 6.5.13