microbio 6.5.13

the properties of a microbe that enhance pathogenicity

• 1.the microbe's ability to replicate rapidly
• 2.how well a microbe attaches to the host (fimbrae, spikes, glycocalyx)
• 3.promote microbial entry

produced by some fungi(ringworm and digest the keratin in skin)

digest hyaluronic acid, intercellular"cementing" substance btween surface cell

digests collagen, most common protein in the body (connective tissue)

covert plasminogen into plasmin, an enzymes that breaks down blood clot.

web-like clot that impedes WBC movement

kills WBC

microbial inhibition of phagocyotisis

toxins disrupt the cell membrane or the internal activities of a cell

G-, are the lipid A part of the outer memebrane ,are relased when G- die, are weak, nonspcific and cause a fever, stimulate weak immunity, are stable( can NOt be denatured and coverted into toxoid,can NOT be used for immunization)

few G+,G-, secreted, polypetide, unstable, POWERFUL, and do NOT cause fever/stimulate strong immunity, can be denatured and coverted to a toxoid which can be used for immunization, and are highly specific! Neurotoxins  &  Enterotoxins

attack the Nervous System (Botulin and tetanospasmin)

attack organs of the digestive tract (shiga and cholera toxin)