Anaplasia

Nuclear morphology of cancer cells?

Hyperchromatia
Normal Nuclear to Cytoplasm Ratio

1:4 or 1:6
Nuclear to Cytoplasm Ratio in Cancer Cells

1:1
Morphology of Mitosis is Cancer Cells

Atypical, Bizzare with multipolar spindles
Dysplasia

Loss of uniformity of individual cells as well as their structural organisation.
Smallest detectable clinical mass of tumor?

1g or 10^9 cells
Number of doublings to produce a clinically detectable mass?

30
Additional doubling to produce 1kg mass?

10
No. of cells in 1kg mass?

10^12
Factors determining rate of growth of tumor?
- 1. Doubling time of cells
- 2.Fraction of tumor in replicative pool
- 3. Rate at which cells shed or die
Growth fraction and chemotherapy

Higher the growth fraction more response to chemotherapy cause the drugs act on cells that are in cell cycle.

Author

priragaa

222164

Card Set

Anaplasia

Description

Features of Anaplasia and Differentiation

Updated

2013-06-03T08:56:56Z