-
-
Coronary vasospasm
Cocaine, sumatriptan, ergot alkyloids
-
Cutaneous flushing
- VANC:
- Vancomycin
- Adenosine
- Niacin
- Ca2+ channel blockers
-
Dilated cardiomyopathy
Doxorubicin (adriamycin), daunorubicin
-
Torsades de pointes
Class III (sotalol), class Ia (quinidine) antiarrhythmics
-
Agranulocytosis
- Clozapine
- Carbamazepine
- Colchicine
- PTU
- Methimazole
- Dapsone
-
Directed Coombs-positive hemolytic anemia
Methyldopa
-
Gray baby syndrome
Chloramphenicol
-
Hemolysis in GPD deficient patient
- (hemolysis IS PAIN)
- Isoniazid
- Sulfonamides
- Primaquine
- Aspirin
- Ibuprofin
- Nitrofurantoin
-
Megaloblastic anemia
- (having a blast with PMS)
- Phenytoin
- Methotrexate
- Sulfa drugs
-
Thrombotic complications
OCPs
-
-
Pulmonary fibrosis
- (it's hard to BLAB when you have pulmonary fibrosis)
- BLeomycin
- Amiodarone
- Busulfan
-
Acute cholestatic hepatitis
Macrolides
-
Focal to massive hepatic necrosis
- Halothane
- Valproic Acid
- Acetaminophen
- Amanita phalloides
-
-
-
Adrenocortical insufficiency
Glucocorticoid withdrawal (HPA supression)
-
Gynecomastia
- (some drugs create awesome knockers)
- Spironolactone
- Digitalis
- Cimetidine
- Alcohole use
- Ketoconazole
-
-
Hypothyroidism
- Lithium
- Amiodarone
- Sulfonamides
-
-
Gout
- Furosemide
- Thiazides
- Niacin
- Cyclosporine
-
-
Photosensitivity
- (SAT for a photo)
- Sulfonamides
- Amiodarone
- Tetracycline
-
Stevens-Johnson Syndrome
- (Everyone Likes Crazy People Always Saying Pretty Please)
- Ethosuximide
- Lamotrigine
- Carbamazepine
- Phenobarbital
- Allopurinol
- Sulfa drugs
- Phenytoin
- PCN
-
Tendonitis, tendon rupture, and cartilage damage (kids)
Fluoroquinolones
-
Fat redistribution
- Glucocorticoids
- Protease inhibitors
-
Myopathies
- (Five Nice Prompt Girl Children Had Intercourse Saturday)
- Fibrates
- Niacin
- Penacillamine
- Glucocorticoids
- Colchicine
- Hydroxychloroquine
- Interferona-alpha
- Statins
-
Fanconi Syndromw
Expired tetracycline
-
Interstitial nephritis
Methicillin, NSAIDs, furosemide
-
Hemorrhagic cystitis
Cyclophosphamide, ifosfamide (prevent via mesna)
-
SIADH
carbamazepine, cyclophosphamide
-
Cinchonisim
Quinidine, quinine
-
Diabetes insipidus
Lithium, demeclocycline
-
Parkinson-like syndrome
- (Hail Mary Christ Resurrected)
- Haloperidol
- Metoclopramide
- Chlorpromazine
- Reserpine
-
Seizures
Bupropion, imipenem/cilastatin, isoniazid, tramadol, enflurane, metoclopramide
-
Tardive dyskinesia
Antipsychotics
-
Disulfiram-like Rxn
Metronidazole, certain cephalosporins, procarbazine, 1st gen sulfonylureas
-
Nephrotoxicity/neurotoxicity
Polymyxins
-
Nephrotoxicity, ototoxicity
Aminoglycosides, vancomycin, loop diuretics, cisplatin
-
Antimuscarinic
Atropine, TCAs, H1-blockers, neuroleptics
-
Acetaminophen
N-acetylcystein (also used for CF)
-
Salicylates
NaHCO3(alkilinize urine), dialysis
-
Amphetamines
NH4Cl(acidify urine)
-
Acetylcholinesterase inhibitors, organophosphates
Atropine, pralidoxime
-
Antimuscarinic, anticholinergic agents
Physostigmine salicylate
-
-
Digitalis
Stop dig, normalize K+, lidocaine, anti-dig Fab fragments, Mg2+
-
Iron, aluminum
Deferoxamine
-
Lead
CaEDTA, dimercaprol, succimer, penicillamine
-
Mercury, arsenic, cold
Dimercaprol (BAL), succimer
-
Copper, arsenic, gold
Penicillamine
-
Cyanide
Nitrite, hydroxocobalamin, thiosulfate
-
Methemoglobin
Methylene blue, vitamin C
-
Carbon dioxide
100% O2, hyperbaric O2
-
Methanol, ethylene glycol (antifreeze)
Ethanol, dialysis, fomepizole(competitive inhibitor of alcohol dehydrogenase)
-
Opioids
Naloxone, naltrexone
-
Benzodiazepines
Flumazenil
-
TCAs
NAHCO3 (plasma alkalinization)
-
-
Warfarin
Vitamin K, french frozen plasma
-
tPA, streptokinase
Aminocaproic acid
-
Theophylline
beta-blocker
-
Night blindness, dry skin
Vitamin A deficiency
-
Arthralgias, fatigue, headaches, skin changes, sore throat, alopecia
Vitamin A excess
-
Wernicke-Korsakoff Syndrome
- Vitamin B1 deficiency (thiamine)
- Dry beriberi- polyneuritis, symmetrical muscle wasting
- Wet beriberi- high-output cardiac failure, edema
-
Cheliosis (inflammation of lips, scaling and fissures at the corners of the mouth), corneal vascularization
Vitamin B2 (riboflavin) deficiency
-
Glossitis, Hartnup disease, pellagra, malignant carcinoid syndrome
Vitamin B3 (niacin) deficiency
-
Derived from tryptophan, requires vitamin B6 for synthesis
Vitamin B3 (niacin)
-
Facial flushing (d/t pharmacologic doses for treatment of hyperlipidemia)
Vitamin B3 (niacin) excess
-
Dermatitis, enteritis, alopecia, adrenal insufficiency
Vitamin B5 (pantothenate) deficiency
-
Convulsions, hyperirritabilit, peripheral neuropathy, sideroblastic anemias
Vitamin B6 (pyridoxine) defiency
deficiency inducible by isoniazid
-
Increased fragility of erythrocytes (hemolytic anemia), muscle weakness, poster column and spinocerebellar tract demyelination (closely mimics Friedrich ataxia)
Vitamin E deficiency
-
Delayed wound healing, hypogonadism, decreased adult hair, dysguesia, anosmia, may predispose to alcoholic cirrhosis
Zinc deficiency
-
Severe fasting hypoglycemia, increase glycogen in liver, increase blood lactate, HSM, seizures
Von Gierke's disease- glucose-6-phosphate
-
Cardiomegaly and systemic findings leading to early death
Pompe's disease - lysosomal alpha1,4 glucosidase (acid maltase)
-
Milder form of Von Gierke's w/ normal blood lactate levels
Cori's disease - Debranching enzyme (alpha1,6 glucosidase)
-
Increased glycogen in muscle that cannot be broken down leading to painful muscle cramps, myoglobinuria w/ strenous exercise
McArdle's disease - glycogen phosphorlyase
-
Peripheral neuropathy of hands/feet, angiokeratomas, CV/renal disease
Fabrys disease - alpha-galactosidase A --> ceramide trihexoside
-
HSM, aseptic necrosis of femur, bone crises, macrophages that look like crumpled tissue paper
Gauchers - beta-glucocerebrosidase
-
progressive neurodegeneration, HSM, cherry-red spot on macla, foam cells
Niemann-Pick disease - sphingomyelinase
-
Progressive neurodegeneration, developmental delay, cherry red spot on macula, lysosomes with onion skin, no HSM
Tay-Sachs - Hexominidase A --> GM2 ganglioside
-
Peripheral neuropathy, developmental delay, optic atrophy, globoid cells
Krabbe's disease - Galactocerebrosidase
-
Central and peripheral demyelination with ataxia, dementia
Metachromatic leukodystrophy - arylsulfatase A - cerebroside sulfate
-
developmental delay, gargoylism, airway obstruction, corneal clouding, HSM
Hurler's syndrome - alpha-L-iduronidase - heparan sulfate, dermatan sulfate
-
aggressive behavior, no corneal clouding
Hunter's syndrome (milder Hurler's) - Iduronate sulfatase - heparan sulfate, dermatan sulfate
-
Failure to thrive, steatorrhea, acanthocytosis, ataxia, night blindess
Abeta-lipoproteinemia
-
1st arch neural crest fails to migrate - mandibular hypoplasia, facial abnormalities
Treacher Collin's Syndrome
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