ASD and FXS

Hagerman and Hagerman 2002: genetic cause of intellectual disability

on x chromosome-> CGG repeats in FMR1-> shuts down production of FMRP (important for brain development)

autistic characteristics: repetitive behaviours, poor eye contact, social avoidance

50% of males may also have autism

• language is more impaired than expected for cognitive ability
• worse in production

fxs with asd worse on receptive language

fxs group performed worse on tom than id matched group (like grant et al 2007)