Karpatkin Cerebellum

  1. cerebellum wt & neurons
    • 10% of brain wt
    • as many neurons as rest of brain combined
  2. inputs and outputs of cerebellum
    • afferent input (from somatic and proprioceptive receptors, visual, vestibular, auditory receptors, motor and nonmotor areas of cerebral cortex)
    • efferent output to brainstem, midbrain ,cerbral cortex, and spinal cord
  3. archicerebellum / vestibulocerebellum fxn
    • gets input just from vestibular system
    • coordination of head and eye mvmnts
    • controls balance
  4. paleocerebellum
    gets input from spinocerebellar, cuneocerebellar, and trigeminal-cerebellar tracts carrying somatosensory info from limbs an dface
  5. neocerebellum
    • inputs from sensory, premotor, and motor cortices
    • works on planning, timing, initiation of vol mvmnts
  6. cerebellum gets sensory input and sends motor output to...
    • brainstem motor nuclei
    • motor and premotor cortices
    • descending motor tracts
    • basal ganglia
  7. basic cerebellum roles
    • postrue
    • equilibrium
    • balance
    • gets feedback from vestib system and sends messages about how to change body pos to deal with this info
  8. Friedgreich's ataxia
    • hereditary
    • CMS and PNS disorders
    • presents at 8-15 y/o w gait disorder
    • then: ataxia, loss of DTRs, impaired proprioception, scoliosis, pes cavus, abnormal eye mvmnts, cardiomyopathy,
    • ataxia due to loss of proprioception and tract involvment (double whammy - lose proprioception & lose control)
  9. olivopontocerebellar atrophy
    • combined degeneration
    • progressive ataxia w later onset
    • initiall pure cerebellar -- later - pyramidal tract, basal ganglia, autonomic signs
  10. deficits that lead to cerebellar problems
    thiamine, B12, and vit E deficiencies

    alcoholism causes the first two
  11. 3 types of neoplasms that cause cerebellar problems
    • primary tumors
    • metastatic disease
    • paraneoplastic syndrome
  12. 3 treatments for cerebellar disorders
    • weighting limb to decrease ataxia (but can also strengthen the ataxic movements)
    • pool - dampens mvmnt, but no functional carryover
    • controll degrees of freedom - limits mvmnt, but doesn't impact the root of the problem
Card Set
Karpatkin Cerebellum
spring 2013