-
Alpha 1:Vascular smooth muscle
Contraction
-
Alpha 1:Papillary dilator muscle
Contraction (mydriasis)
-
Alpha 1:Pilomotor smooth muscle
Piloerection
-
Alpha 1:Prostate capsule
Contraction
-
Alpha 1:Spleen
Contraction
-
Alpha 1:GI tract sphincters
Contraction
-
Alpha 1:Urinary bladder sphincter
Contraction
-
Alpha 1:Pregnant uterus
Contraction
-
Alpha 1:Male sex organ
Ejaculation
-
Alpha 2:Platelets
Aggregation
-
Alpha 2:Adrenergic n. terminals
Inhibit NE release
-
Alpha 2:Cholinergic n. terminals
Inhibit Ach release
-
Alpha 2:GI secretory cells
Inhibit secretion
-
Alpha 2:Fat cells
Inhibit lipolysis
-
Alpha 2:Enteric cholinergic nn.
Inhibit ACh release/relax GI sm. m.
-
Alpha 2:Pancreas
Reduce insulin secretion
-
Alpha 2:Post. Syn brainstem adrenoreceptors
Reduces sympathetic n. activity
-
B1:Heart
increased inotropy, chronotropy, dromotropy
-
B1:Kidney
Increase rennin release
-
Beta 2:Trachea/bronchioles
Relaxation
-
Beta 2:Bronchial glands
Increased secretion
-
Beta 2:Vascular smooth muscle
Relaxation
-
Beta 2:Pancreas
Increase insulin secretion
-
Beta 2:Nonpregnant uterus
Relaxation
-
Beta 2:Mast cells
Reduce inflam. Mediator release
-
Beta 2:Skeletal muscle
Increase potassium transport
-
Beta 1&2:Gallbladder
Relaxation
-
Beta 1&2:GI tract
Relaxation
-
Beta 1&2:Detrusor muscle
Relaxation
-
Beta 1&2:Liver
Glycogenolysis
-
Beta 3:Fat cells
Lipolysis (beta 3)
-
Ach:Vascular endothelial cells
NO release and vasodilation
-
Ach:Iris (sphincter m.)
Contraction (miosis)
-
Ach:Ciliary m.
Contraction (accommodation)
-
Ach:Salivary/lacrimal glands
Thin/watery secretion
-
Ach:Bronchi
Constriction/increased secretion
-
Ach:Heart
Bradycardia/slowed AV conduction/slight decrease in contractility
-
Ach:GI tract
Increased tone/secretions/sphincter relaxation
-
Ach:Urinary bladder
Detrusor contraction/sphincter relaxation
-
Ach:Sweat glands
Diaphoresis
-
Ach:Male sex organ
erection
-
-
M1*
Autonomic ganglia/CNS
-
M2**
Myocardium (SA/AV nodes), sm. m., autonomic n. terminals (ganglia & adrenergic nn.)
-
-
-
M5*
- Low levels in CNS
- * IP3/DAG/PLC/depol./slow EPSP
- ** Adenylyl cycl inhibition/reduce cAMP/ K+ ch. Opened (hyperpol.)
-
Alpha 2- Rs
Inhibition of Processes
-
Alpha 1-Rs
Contraction of smooth muscle
-
Beta-Rs
Relaxation of SM. M or increased secretion
-
Ach
Used by: NMJ, Pre gang anything, Post gang Parasymp, and sweat glands of symp.
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