PHA 327-Biopharmaceutics

  1. What is biopharmaceutics?
    The study of the relationship between the Physico-chemical and in vitro behavior of the drug
  2. What is the target of biopharmaceutical studies?
    To enhance the delivery and the therapeutic effects of drugs in the patient
  3. What are the BCS classes?
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    • Class I - IV
  4. What is BCS stand for?
    Biopharmaceutics class system
  5. BCS class I has what characteristics?
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    • Highly soluble
    • High permeation of the Jejunum
  6. BCS class II has what characteristics?
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    • Low solubility
    • High permeation of the Jejunum
  7. BCS class III has what characteristics?
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    • Highly soluble
    • Low permeation of the Jejunum
  8. BCS class IV has what characteristics?
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    • Low solublity
    • Low permeation of the Jejunum
  9. What are the three aspects that separate the BCS classes?
    • Solubility
    • Permeability
    • Dissolution
  10. What is the main difference between two different polymorphic forms of a drug?
    1. Crystal structures
  11. What are the seven dosage form factors discussed?
    • pH/pKa
    • Hygroscopicity
    • Particle size
    • Excipient interaction
    • stability profile
    • Partition coefficient
    • Polymorphism
  12. What drug action changes with differing particle size?
    • Smaller PS = higher doses earlier with that do not last long
    • Larger PS = Lower doses, later slower elimination
  13. The more lubricant added to a dosage form equates to what changes in plasma drug level?
    More lubricant = lower Cmax, later tmax
  14. What does in vitro dissolution testing equate to?
    In vivo pharmacokinetic profile
  15. In vivo pharmacokinetic profile correlates with what?
    In vitro dissolution testing
  16. Which oral formulation would likely have the most delayed tmax value?
  17. When medications are injected, what usually happens to normal body functions?
    They operate as normal
  18. What general system do normal body functions have an effect on?
    drug pharmacokinetics
  19. What factors increase gastric emptying?
    • Stress
    • Standing
    • Lying on the right side
    • Light exercise
    • Spasmogenic agents (e.g. erythromycin, metoclopramide)
  20. What factors decrease gastric emptying?
    • Long chain fatty acids
    • Triglycerides
    • Large particles/objects
    • Ingested solids
    • Increasing pH
    • Lying flat
    • Lying on the left side
    • Vigorous exercise
    • Depression
    • Anticholinergic drugs
    • Narcotics
    • Ethanol
  21. What factor can alter the state of GI transit?
    Fasted and Fed states
  22. How do liquid and solid gastric emptying rates compare:
    • Solids empty slowly and linearly
    • Liquids empty quickly and exponentially
  23. Do all drugs follow the same pattern based on gastric content and Fasted/Fed states?
  24. What happens to the lungs with TB?
    Cilia disappear
  25. What is aveolar clearance?
    • The removal of particles in the lung by macrophages
    • Usually a rapid process
  26. What is the diamter of Aveolus?
    0.2 mm
  27. What is the Diameter of the terminal Bronchiole?
  28. What is the diameter of the bronchus?
  29. What type of particles are primarily affected by Diffusion/Brownian motion?
    Very fine (60-100 nanometer)
  30. What is lung sedimentation affected by?
    Density and size
  31. What are inertial or Impact factors in the lung affected by?
    • Velocity
    • Density
    • Particle size
  32. What is MMAD stand for?
    Mass median aerodynamic diameter
  33. What limits the available dosage forms?
    The route of administration
  34. Does the dosage form limit the route of administration?
    No too much
  35. Describe the Cmax and Tmax of IV, IM and Oral dosage forms:
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    • IV = High Cmax, Early Tmax
    • IM = mid Cmax, Mic Tmax
    • Oral = Low Cmax, Late Tmax
  36. What is affected by all pharmacodynamic processes in a system?
  37. What two pharmacokinetic parameters are described by Bioavailability?
    Rate and Extent of absorption
Card Set
PHA 327-Biopharmaceutics
PHA 327-Biopharmaceutics