Pharmacology: respiratory medications

  1. The purpose of respiratory drugs is to:
    relieve bronchoconstriction and increase ventilation and oxygen delivery at the cellular level
  2. Brhoncodilators (albuterol) mechanism of action is what?
    • selective Beta 2 agonist
    • increase the levels of cAMP in B2 receptors
    • Promote the release of insulin
  3. Indications to use albuterol include what?
    • bronchospasm associated with COPD/emphysema, and asthma
    • acute bronchitis
    • Hyperkalemia (off label)
  4. What are contraindications for albuterol?
    • Tachycardia (relative)-assess if tachycardia is from hypoxia
    • tachyarrythmias
    • severe heart disease
    • heart blocks
    • and seizure disorders
  5. Common side effects of albuterol include what?
    • palpitations
    • tachycardia
    • n/v
    • tremor
    • anxiety
    • ha
    • cp
    • HTN
    • and less common:
    • hypotension 
    • hyperglycemia
    • hypokalemia
    • LA
    • Bronchospasm when used with beta blockers
  6. Terbutaline is a ________
  7. what is Terbutaline's off label use?
    Used as a tocolytic
  8. terbutaline's mechanism of action is ________
    • selective b2 agonist 
    • relaxes uterine muscles
  9. Terbutaline may cause________
    • increased HR
    • transient hyperglycemia
    • hypokalemia
    • arrhythmias
    • pulmonary edema
    • myocardial ischemia
  10. the mechanism of action is the same as epinephrine but produces half the physiologic effects of epinepherine for this drug
    racemic epinephrine
  11. This drug is indicated in Croup but contraindicated in epiglottitis
    racemic epi
  12. what class of med is Ipratropium bromide (atrovent)
  13. Dries respiratory tract secretions and causes bronchodilation
  14. These drugs decrease inflammation by suppressing the activation/migration of polymorphonuclear leukocytes, reducing capillary permeability and stabilizes lysosomes
    corticosteroids (methylprednisolone, solumedrol)
  15. Treats severe status asthmaticus, inflammatory illness, allergic reaction, and adrenergic insufficiency and management of shock
    solu-medrol (methylprednisolone)
  16. Off label uses include exacerbation of COPD, management of acute spinal cord injuries, ARDS
    methylprednisolone (solumedrol)
  17. Solu-medrol side effects include:
    • n/v
    • fluid retention (decompensation in CHF)
    • hypertension
    • Hyperglycemia
    • GI hemorrhage
  18. Theophylline is used to treat______
    bronchospasm secondary to restrictive airway disease refractory to other medication treatment an apnea associated with prematurity
  19. Smooth muscle relaxant
  20. Prolongs conduction time, stabilizes excitable membranes, is necessary for the movement of calcium, sodium, and k in and out of cells
  21. Magnesium is indicated in
    • severe exacerbation of asthma
    • eclamptic seizures
    • premature labor
    • reduce absorption of poisons from gi tract
    • dysrhythmias secondary to digitalis toxicity and tricylic antidepressant overdose
  22. magnesium is contraindicated in
    • heart block
    • addisons's disease
    • severe hepatitis
  23. potent alpha and beta adrenergic agonist that is 
    chronotrop, inotrop, peripheral vasoconstrictor, increased automaticity and conduction, and bronchodilation
    epi 1:1000
  24. Indications for epi 1:1000
    exacerbation of ashtma, copd, anaphylaxis
  25. increases blood flow to areas of lung that are ventilated to reverse v/q mismatching
    Nitric oxide
  26. effects are quickly deactivated once it reaches the bloodstream and reacts with hemoglobin which prevents vasodilation beyond pulmonary circulation
    Nitric oxide
  27. prolonged exposure to >2ppm of the byproduct (which is produced as it mixes with O2) of this drug can be injurious to the lungs
    nitric oxide
Card Set
Pharmacology: respiratory medications
taken from course declaratives