Chapter 16 The Endocrine System (TB)

  1. Gluconeogenesis occurs in the liver due to the action of ________.

    D) cortisol
  2. Normal development of the immune response is due in part to hormones produced by the ________.

    A) thymus gland
  3. Virtually all of the protein or amino acid-based hormones exert their effects through intracellular ________.

    C) second messengers
  4. Which of the following is not a category of endocrine gland stimulus?

    A) enzyme
  5. Chemical substances secreted by cells into the extracellular fluids and that regulate the metabolic function of other cells in the body are called ________.

    A) hormones
  6. The hypothalamic-hypophyseal tract ________.

    B) is partly contained within the infundibulum
  7. Which of the following is not a cardinal sign of diabetes mellitus?

    B) All of these are signs.
  8. Which of the choices below is not a factor required for target cell activation by hormone receptor interaction?

    C) type of hormone
  9. Oxytocin ________.

    D) release is an example of a positive feedback control mechanism
  10. ADH ________.

    C) is inhibited by alcohol
  11. Thyroid hormone exerts its influence by ________.

    A) entering some cells and binding to intracellular receptors within the nuclei
  12. Gonadocorticoid(s) ________.

    A) production by the adrenal gland is insignificant compared with sex hormone release from the gonads during late puberty
  13. Sometimes prolonged excessive exposure to high hormone concentrations causes a phenomenon known as ________.

    C) down-regulation
  14. Which of the following is not a change that may be caused by hormonal stimulus?

    D) direct control of the nervous system
  15. The ability of a specific tissue or organ to respond to the presence of a hormone is dependent on ________.

    D) the presence of the appropriate receptors on the cells of the target tissue or organ
  16. Several hormones are synthesized in the hypothalamus and transported to the anterior pituitary gland. The mechanism of transportation from hypothalamus to anterior pituitary gland is through the ________.

    B) hypophyseal portal system
  17. The neurohypophysis or posterior lobe of the pituitary gland is not a true endocrine gland because ________.

    D) it is only a hormone storage area that receives hormones from the hypothalamus for release
  18. Steroid hormones exert their action by ________.

    D) entering the nucleus of a cell and initiating or altering the expression of a gene
  19. The second-messenger mechanism of hormone action operates by ________.

    B) binding to specific receptors and employing the services of G proteins and cAMP
  20. Hormones often cause a cell to elicit multiple responses; this is because ________.

    A) during protein kinase activation, enzymes phosphorylate many other enzymes
  21. Cells that respond to peptide hormones usually do so through a sequence of biochemical reactions involving receptor and kinase activation. In order for cells to respond, it is necessary for first and second messengers to communicate. This is possible because ________.

    B) G protein acts as the link between first and second messengers
  22. Thyroid hormone (a small iodinated amine) enters target cells in a manner similar to ________.

    A) steroid hormones, because both diffuse easily into target cells
  23. When it becomes necessary to enlist the fight-or-flight response, a hormone that is released during the alarm phase of the general adaptation syndrome is ________.

    C) epinephrine
  24. One of the least complicated of the endocrine control systems directly responds to changing blood levels of ions and nutrients. Which of the following describes this mechanism?

    B) humoral stimulation
  25. The major targets of growth hormone are ________.

    C) bones and skeletal muscles
  26. The parathyroid glands maintain adequate levels of blood calcium. This is accomplished through ________.

    D) targeting the bone and activating osteoclasts so that calcium will be released
  27. Which organ is responsible for synthesizing ANP?

    A) the heart
  28. Mineralocorticoid is to aldosterone as glucocorticoid is to ________.

    A) cortisol
  29. Leptin is secreted by ________.

    D) adipocytes
  30. The most important regulator of electrolyte concentrations in extracellular fluids is ________.

    B) aldosterone
  31. Which of the following is not a steroid-based hormone?

    A) epinephrine
  32. Which of the following would be associated with the action of steroids on cells?

    D) a hormone-receptor complex that interacts directly with the cell's DNA
  33. Cellular responses to hormones that initiate second-messenger systems include ________.

    D) possible activation of several different second-messenger systems
  34. Regulating hormones from the hypothalamus ________.

    B) first enter into the hypophyseal portal system
  35. ACTH ________.

    C) secretion is regulated by a hypothalamic secretion
  36. Which of the following is true about calcium homeostasis?

    A) Parathyroid hormone is the single most important regulator of calcium levels in the blood.
  37. Aldosterone ________.

    C) functions to increase sodium reabsorption
  38. The only amine hormone to act like a steroid is ________.

    A) TH
  39. Which organ does not have hormone production?

    C) liver
  40. In circumstances where the body requires prolonged or increased levels of a hormone, the DNA of target cells will specify the synthesis of more receptors on the surface of the cells of the target organ. This is known as ________.

    C) up-regulation
  41. Eicosanoids do not include ________.

    D) hydrocortisones
  42. A man has been told that he is not synthesizing enough follicle-stimulating hormone (FSH), and for this reason he may be unable to father a child. Choose the correct statement to explain this problem.

    A) FSH stimulates sperm production in the testes.
  43. Which of the following organs is affected by thyroid hormone in adults?

    C) liver
  44. Thyroxine is a peptide hormone, but its mechanism is different from other peptide hormones. Which of the following statements is true concerning this difference?

    A) It does not require a second messenger to effect a response.
  45. How do glucocorticoids enable the body to deal appropriately with stress?

    D) by increasing blood glucose, fatty acid, and amino acid levels and enhancing blood pressure
  46. What ion is sometimes used as a second messenger of amino acid based hormones?

    D) calcium
  47. ________ are hormones synthesized from cholesterol.
  48. ________ is a hormone that has only one known effect: to stimulate milk production by the breasts.
  49. ________ are the result of hypersecretion of growth hormone.
    Acromegaly and gigantism
  50. The largest pure endocrine gland in the body is the ________.
  51. Which hormone stimulates production of RBCs and which organ or structure produces it?
    erythropoietin; kidney
  52. Alpha islet cells produce ________, an extremely potent hyperglycemic hormone.
  53. The ________ gland may influence our day/night cycles and even regulate the onset of sexual maturity.
  54. The ________ gland declines in size and function with age.
  55. Endocrine gland stimuli include hormonal, ________, and ________ stimuli.
    humoral; neural
  56. As a result of stress the adenohypophysis releases ________, which stimulates release of hormones from the adrenal cortex that retain sodium and water, increase blood sugar, and begin breaking down fats.
  57. In humans, melatonin may inhibit sexual maturation. True or False
  58. The antagonistic hormones that regulate the blood calcium level are calcitonin-parathormone. True or False
  59. The hormone that raises blood sugar levels is insulin. True or False
    False; lowers
  60. Addison's disease is due to a deficit output of glucocorticoids only. True or False
  61. Both "turn on" factors (hormonal, humoral, and neural stimuli) and "turn off" factors (feedback inhibition and others) may be modulated by the activity of the nervous system. True or False
  62. ACTH stimulates the adrenal cortex to release corticosteroid hormones. True or False
  63. LH is also referred to as a gonadotropin. True or False
  64. With age, chronic stress increases blood levels of cortisol and appears to contribute to memory deterioration. True or False
  65. Oxytocin is a strong stimulant of uterine contractions. True or False
  66. Follicle cells of the thyroid gland produce thyroglobulin, while follicle cells of the parathyroid produce calcitonin. True or False
  67. Type 2 diabetics may reflect declining receptor sensitivity to insulin rather than decreased insulin production. True or False
  68. The prime metabolic effect of cortisol is gluconeogenesis. True or False
  69. The beta cells are the pancreatic islet cells that produce insulin. True or False
  70. Most type 2 diabetics do not produce insulin. True or False
  71. Aldosterone is the most potent mineralocorticoid produced in the adrenals but the least abundant. True or False
  72. Atrial natriuretic peptide is a hormone that controls blood pressure in part by increasing the urinary excretion of sodium. True or False
  73. Although glucagon is a small polypeptide, it is nevertheless very potent in its regulatory effects. True or False
  74. The thyroid gland is a large gland that controls metabolic functions throughout the life of an individual. True or False
  75. Many hormones synthesized in the gastrointestinal tract are chemically identical to brain neurotransmitters. True or False
  76. All of the following hormones are secreted by the adenohypophysis: ACTH, FSH, and LH. True or False
  77. Iodine is an essential element required for the synthesis of thyroxine. True or False
  78. The endocrine gland that is probably malfunctioning if a person has a high metabolic rate is the parathyroid. True or False
  79. Growth hormone always exerts its influence by targeting other endocrine glands to produce hormones. True or False
  80. Glucocorticoids are steroid hormones that usually enhance the immune responses when an individual is suffering from severe stress. True or False
  81. Direct gene activation involves a second-messenger system. True or False
  82. All peptide hormone synthesis requires gene activation that produces mRNA. True or False
  83. All adenohypophyseal hormones except GH affect their target cells via a cyclic AMP second messenger. True or False
Card Set
Chapter 16 The Endocrine System (TB)
Biology 103A