PTG 105-Exam 4-Soft Tissue 3

  1. How common is Rhabdomyoma?
  2. What other disease can rhabdomyoma occur with?
    Tuberous sclerosis
  3. At what stage in life does Rhabdomyosarcoma occur?
    Infancy through first decade
  4. What is the most common sarcoma in children?
  5. Children from 2-8 usually develop Rhabdomyosarcoma in what body areas?
    • Head
    • Neck Genitourinary
  6. Teenagers from 14-18 usually develop Rhabdomyosarcoma in what areas of the body?
    • Abdominal
    • Paratesticular
    • Trunk
  7. What are the three subtypes of Rhabdomyosarcoma?
    • Pleomorphic
    • Aveolar
    • Embryonal
  8. What characteristic indicates Aveolar Rhabdomyosarcoma?
    Chromosomal translocation t(2, 13)
  9. What disease typically shows chromostomal translocation t(2,13)
    Aveolar Rhabdomyosarcoma
  10. What are long thin cells associated with Rhabdomyosarcoma called?
    Strap cells
  11. What cells are often seen on a slide of Rhabdomyosarcoma?
    • Strap cells
    • Myoblasts
  12. What is the name for a benign smooth muscle tumor?
  13. Where are Leiomyomas usually found?
    • Uterus
    • Sometimes subcutaneous
  14. What is the most common neoplasm in women?
  15. What is the histology of Leiomyoma?
    • Blunt ended, elongated nuclei
    • Minimal atypia
    • Minimal mitosis
    • No coagulative tumor necrosis
  16. What type of tumor would you expect to have blunt ended, elongated nuclei, little atypia and mitosis and no coagulative necrosis factor?
  17. What percent of adult soft tissue sarcomas are Leiomyosarcoma?
  18. What sex is more likely to develop Leiomyosarcoma?
  19. Where is a common site for metastasis of Leiomyosarcoma?
    The lung
  20. What are common sites for Leiomyosarcoma?
    • Extremities
    • Lumen of vessels (inferior vena cava, saphenous vein)
  21. What would you expect to see on a slide of Leiomyosarcoma?
    • High mitotic activity
    • High pleomorphism
    • Tumor cell necrosis
  22. What is synovial sarcoma?
    Deep seated tumor around large joints, usually in young adults
  23. Where are most synovial sarcomas located?
    80% at the knee or ankle
  24. What age range is typical for synovial sarcoma?
    20-40 years
  25. How often does synovial sarcoma metastasize?
  26. Where does synovial sarcoma metastasize to?
    • Lung
    • Pleura
    • Bone
    • Regional lymph nodes
  27. What usually causes Synovial sarcoma?
    Chromosomal translocation t(X;18), (p11.2; q11)
  28. What percent of people with synovial sarcoma also have chromosomal translocation?
  29. What is characteristic of the histology of synovial sarcoma?
    • Biphasic
    • Spindle cells stroma and Round epithelial cells that form glands
  30. What type of tumor has a biphasic histological appearance with spindle cells and round epithelial cells mixed as glands?
    Synovial sarcoma
  31. What are the important cell types of the epidermis?
    • Melanocytes
    • Squamous epithelial cells
  32. What is another name for squamous epithelial cells of the epidermis?
  33. What are the major components of the dermis?
    • Blood vessels
    • Hair follicles
    • Sebaceous glands
    • Sweat glands
  34. Describe a Papule:
    Elevated solid area (plaque)
  35. What is an elevated solid area on the skin?
    Papule (Plaque)
  36. What is a Macule?
    Flat area of coloration on the skin
  37. What is the term for a flat area of coloration on the skin?
  38. What is a Nodule?
    A solid area larger than a papule
Card Set
PTG 105-Exam 4-Soft Tissue 3
PTG 105-Exam 4-Soft Tissue 3