pharma II test IV adrenocortical hormones

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4 organ and tissue effects of glucocorticoids at higher concentrations
- lymphocytopenia-immunosuppression
- stabilizes lysozymes-protects against apoptosis
- antiinflammatory-inhibit mass cell/basophils
- osteoporosis - thinning of compact bone
secondary adrenocortical insufficiency results from what

decreased secretion of ACTH (pituitary)
tertiary adrenocortical insufficiency results from what

decreased secretion of CRF (hypothalamus)
corticosteroid inhibitor
moa - inhibits synthesis of cortisol but not that of cortisol presursors
ind - for diagnostic tests of adrenal function

metyrapone - metopirone
corticosteroid inhibitor
moa - blocks conversion of cholesterol to pregnenolone
ind - adjunct in treatment of steroid-producing adrenocortical cancer

aminoglutethimide
corticosteroid inhibitor
moa - blocks sterol synthesis
ind - adjunct for adrenal carcinoma, hirstism, breast and prostate cancer

ketocnazole
corticosteroid inhibitor
moa - binds to glucocorticoid receptor & inhibits release of HSP-complex
ind - Tx of cushing's syndrome

mifepristone - RU486
coritcosteroid inhibitor
moa - antagonist of aldosterone at receptor
- spironolactone
- eplereone
mineralcoritcoid
antiinflammatory
large salt retention (250X)

fludrocortisone - florinef
mineralcorticoid
no antiinflammatory
lower salt retention (20X)

desoxycorticosterone - DOC
excessive adrenal secretion
primary hyperaldosteronism

Conn's syndrome
Tx of Conn's syndrome
- surgery
- spironolactone
- ACEI
secondary hyperaldosteronism

hyperactivity of renin-angiotensin system
excessive adrenal secretion
congenital adrenal hyperplasia
- deficiency of 21b-hydroxylase
- decrease glucocorticoids
- pituitary compensates, increase ACTH release = increased androgen production
Tx of congenital adrenal hyperplasia

glucocorticoid administration for life
4 indications for corticosteroids
- allergic reactions
- inflammatory disorders
- lymphatic leukemia
- brain injury, MI
adverse effect of glucocorticoid

cushing's disease
Tx of acute adrenal insufficiency (adrenal crisis)
- fluids
- salts
- glucose
- glucocorticoids
disease of primary adrenocortical insufficiency
- addison's disease
- skin pigmentation
Tx of addison's disease

life-long glucocrticoids and mineralcorticoids
2 long acting glucocorticoids
- betamethasone - celestone
- dexamethasone - decadron
2 intermediate acting glucocorticoids
- triamcinolone - aristocort
- fluprednisolone
5 short acting glucocorticoids
- prednisone - deltasone
- cortisol - hydrocortisone
- cortisone
- prednisolone
- methylprednisolone - medrol
3 ways glucocorticoids raise blood sugar levels
- catabolic effect - proteins are broken down to amino acids
- amino acids are converted to sugar - other than carbohydrates
- sugars are converted to fat

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pharma II test IV adrenocortical hormones

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pharma II test IV adrenocortical hormones

Updated

2013-05-02T04:29:24Z

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