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BIOL 404-Exam 4-Muscle 10
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What is the action of Curare?
Competitively binds to Nicotinic receptors without opening their ion channels
Cannot be destroyed by Acetylcholine esterase
What were the three non-depolarizing neuromuscular junction blocking drugs discussed in class?
Curare
Rocuronium
Vecuronium
What are Curare, Vecuronium and Rocuronium?
Non-depolarizing neuromuscular junction blockers
What is the advantage of Vecuroniuma nd Rocuronium?
Longer acting than Curare
What muscle related drug can cause death by asphyxiation?
Curare, as it can inhibit muscles required for breathing
Other than non-depolarizing nicotinic competitive inhibitors, what alternate mechanisms are there for blocking neuromuscular transmission?
inhibition of acetylcholineesterase
What are examples of toxins that inhibit acetylcholinesterase?
Organo-phosphates
Found in nerve gas and fertilizers
What is Succinylcholine?
Depolarizing/Desensitizing acetylcholine receptors Antagonist
Works similarly to acetylcolinesterase inhibitors
Succinylcholine works similarly to what other drugs?
Acetylcholinesterase inhibitors
What is the action of Succinylcholine?
Depolarizing/Desensitizing acetylcholine receptors Antagonist
What is the generally potency of Botulism toxin?
One of the most potent toxins
Need very little to produce and effect
What bacteria produces Botulism?
Clostridium Botulinum
What is Botulism toxin?
An enzyme that breaks down the SNARE complex rquired for fusion of ACh vesicles with axon terminal
What is the name for the substance that breaks down SNARE complexes, required for ACh binding to the axon terminal?
Botulsim toxin
What are common uses for Botulism toxin?
Overactive extraocular muscles
Excessive sweat gland activity
Treatment for migraines
Wrinkles
Describe the structure of smooth muscle:
1-2 um wide
50-400 um long
Spindle shaped
How does the size of smooth muscle compare to the size of skeletal muscle?
Much smaller
What are the dimensions of skeletal muscle?
10-100 um wide and can be tens of centimeters long
How many nuclei do smooth muscle cells contain?
1
When do smooth muscle cells cease to divide?
Never, can continually divide throughout a lifetime
What filament component is not found in Smooth Muscle?
Troponin
What type of cells would you not expect to find Troponin?
Smooth muscle cells
What filament components would you expect to find in smooth muscle?
Actin
myosin
Tropomyosin
What are think filaments in smooth muscle cells anchored to?
Plasma membrane or Dense bodies
Describe the banding pattern of smooth muscle cells?
No banding pattern due to lack of sarcomeres and myofibrils
What type of muscle cell does not have myofibrils, sarcomeres or a banding pattern?
Smooth muscle cells
What is the mechanism for smooth muscle contraction?
Sliding filament mechanism
Where are smooth muscles found?
Surrounding hollow organs that undergo changes in volume
Author
kyleannkelsey
ID
217031
Card Set
BIOL 404-Exam 4-Muscle 10
Description
BIOL 404-Exam 4-Muscle 10
Updated
2013-05-01T16:32:51Z
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