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Name some microcytic, hypochromic anemias
Fe deficiency, thalassemia, anemia of chronic disease (inflammation) of long duration
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Labs in anemia of chronic disease.
Hgb most often 8-10. MCV and MCHC normal, so normocytic and normochromic but may progress to microcytic with time. Retic count often below normal. Not producing many new RBCs.
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What MCV levels are considered microcytic?
below 80 fL
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What MCV levels are considered macrocytic?
100+ fL
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what does fL stand for in the MCV measurement?
femtoliters
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How is MCV arrived at?
hematocrit divided by total RBCs multiplied by 10
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Some causes of macrocytic anemia.
B12 or folate deficiency, alcoholism, liver dz
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presence of abnormal cells in the circulation (eg, nucleated RBCs, blasts, atypical mononuclear cells) and/or abnormal increases or decreases in absolute counts for granulocytes, lymphocytes, monocytes, or platelets indicates what?
complex hematological dz such as leukemia, aplastic anemia, etc
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Some lab findings in patient with sickle cell dz
- reticulocytosis of 3 to 15 percent, unconjugated hyperbilirubinemia,
- elevated serum lactate dehydrogenase, and low serum haptoglobin
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What major lab finding is usually present with a hemolytic anemia.
Increase in reticulocyte count.
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nml eosinophil percentage in CBC
1-4%
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normal neutrophil percentage in CBC
40-60%
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normal lymphocyte percentage in CBC
20-40%
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