med chem III test IV cancer conceptual

resting cell ratio related to cell cycle

3 properties unique to cancer cells

3 tumor cell properties that could present problems

4 mechanisms for drug resistance

4 bad results of tumor lysis syndrome

tumor lysis causing metabolic and electrolyte disturbances can progress to 4

causes chemotherapy-induced hyperpigmentation of the tongue

preventative vaccine against strains of HPV attributed to cause 70% of cervical cancers

therapeutic vaccine which utilizes personalized medicine to treat prostate cancer

disrupt DNA synthesis
block mitosis
disrupt protein synthesis
target cell replication
cycle specific and non

act during any phase
synergistic w/cell cycle specific drugs
more toxic to proliferatind cells

3 criteria for cancer drug therapy

which drug class causes a formation of a covalent bond between drug and DNA to form crosslinks
methylation at N7

Administer with caution in hepatic failure, DO NOT take this drug with calcium containing foods (dairy products) or antacids, thrombosis and hypertension possible side effects
USE contraception due to mutagenic, carcinogen and tetratogenic potential

DNA virus agent

RNA virus agent

MOA: Spindle poison – unique mechanism such that these drugs promote assembly of microtubules and stabilize them such that
depolymerization can not occur

cytotoxic intercalation
not cell cycle specific
streptomyces or streptococcus origin
most have I.V administration

DNA cleavage agents
significant antitumor activity
minimal myelosupression
pulmonary fibrosis

aquation or hydration necessary to produce active species
explains difference in pharmacokinetics and potency

Side-effects include:    
Hepatotoxicity & renal damage
severe vomiting
ototoxicity (more severe in children)
Analyphylaxis (immediate-treat with epinephrine, antihistamines,corticosteroids)

Bone marrow suppression is dose related producing infection and
anemia---may be cumulative and require transfusions
Dosage adjustment a function of renal creatinine clearance
Carefully monitor platelet and neutrophil counts
DO NOT use aluminum containing administration sets

target post menopausal women
blocks estrone and estradiol production
does not block ovarian production in pre-menopausal women

Nonreceptor TK’s
Maintained in the inactive state by

These inhibitors also induce growth arrest, cell differentiation, and apoptosis of tumor cells.