Microbiology

Red Blood Cells

Platelets

White Blood Cell

• Granulocyte
• 70% of circulating WBC
• First WBC to infection
• High mortality rate
• Function- phagocyte; eat one microbe and die

• Granulocyte
• 1% circulating in blood stream
• Release histamine and trigger inflammation
• Allergies

• Granulocyte
• Fixed in tissues
• Histamine granules
• Prevalent in skin/respiratory tissues
• Allergies

• Granulocyte
• Eukaryotic parasite response
• Phagocytic
• Release toxin granules
• Increase allergy/asthma levels
• Hygiene Hypothesis

• Agranulocyte
• Found in blood tissue
• Immature macrophages
• Phagocyte

• Monocyte
• Found in every tissue
• (mostly spleen/lymph nodes)
• Filters fluids through tissue

• Monocyte
• Move with pseudopods
• Go to infection to "clean up"

• Lymphocyte
• Cell mediated immunity (3rd line)
•  

• Lymphocyte
• Make Antibodies

• Lymphocyte
• Destroy target cells

• Cytokine
• Chemotaxis signal for WBC
• Induce migration of phagocytes into the infection site

• Cytokine
• Tumor necrosis factor (TNF) acute proteins
• Histamine- kinin, prostaglandins, leukotrienes-vasodilation

• Cytokine
• IFN anti-viral protein production

• Cytokine
• Control blood stem cell differentiation to make new blood cells

Large protein or polysaccharide

Specific region on antigen that is bound by the antibody

Small molecule that can trigger immune response if bound to large carrier molecule

• Bind to mast cells and basophils
• Act as pseudo receptors
• Involved in allergy response

• B cell surface receptors
• Required to activate B cells

• Found in both secretions and on mucous membranes
• Most abundant Ig in BODY
• Neutralization which blocks attachment
• Diamer

• Monomer form: B cell receptors
• Pentameter form: secretions

• Major circulation Ab in serum (80%)
• Secondary antibody for the SECOND exposure
• Monomer: high affinity for binding; can enter tissues
• Neutralized toxins and strongly triggers the complement cascade