Antineoplastics #5

• Amifostine -- Ethyol
• Dexrazoxane -- Zinecand
• Mesna sodium -- Mesnex

• thiol phosphate prodrug
• scavenges toxic platinum metabolites

• extravasation from IV anthracyclines (doxirubicin)
• prodrug of EDTA

• Ifosfamide and cyclophosphamide induced hemorrhagic cystitis
• thiol group scavenges acrolein

• induces maturation of blood cell presursors
• teratogen

• promote cellular differentiation and proliferation
• teratogen

• protein-tyrosine kinase inhibitor
• metab -- 3A4
• tyrosine kinase inhibitors -- many drug interactions with 3A4

• prevents phosphorylation and arrests G1 phase and decreases expression of VEGF
• metab -- 3A4
• found on drug-eluting stents

• prevents phosphorylation and arrests G1 phase and decreases expression of VEGF
• use caution in p-glycoprotein inibitors
• 3A4 inducer and inhibitor

• boron based 26s proteasome inhibitor
• painful non life threatening skin rashes

tetrapeptide epoxyketone proteasome inhibitor

binds and inhibits Smoothened, a transmembrane protein involved in Hedgehog signal transduction

inhibits histone deacetylase

• IV depsipeptide agent
• inhibits histone deacetylase

• induces oxidative stress
• orphan drug for metastatic melanoma

• prostate cancer
• androgen biosynthesis inhibitor of CYP17
• stops production of testosterone

• photodynamic therapy
• photosensitizing agent by laser light generating oxygen free radicals
• pallative tx for lung cancer

• suppresses adrenal fx and production of adrenal steroids
• can cause brain damage and depression
• similar to DDT

• low systemic toxicity
• improves biological half life

• immunogenicity of protein is decreased
• All tumor cells lack L-asparagine synthase
• depletes L-asparagine fomr tumor cell -- cytotoxic

• reduces severe mucositis
• increases proliferation differentiation and migration of epithelial cells