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Mitotic Inhibitors -- drugs
- Vincristine
- Vinblastine
- Vinorelbine
- Paclitaxel
- Docetaxel
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Vincristine
- tubulin inhibitor
- causes neuropathies
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Vinblastine
- tubluin inhibitor
- very toxic to bone marrow
- minimal neurotoxicity
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vincristine and vinblastine
- very painful extravastion
- 3A4
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vinorelbine -- Navelbine
- granulocytopenia
- neurotoxicity
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Paclitaxel -- Taxol and Docetaxel -- Taxotere
- acts in G2 to forn microtubule bundles
- 24 hr infusion
- metastatic breast cancer
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Taxoids
- Spindle poison
- cells can't divide
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Docetaxel -- Taxotere
- used in combo with 5-FU and cisplatin
- 3A4
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Cabazitaxel -- Jevtana
- premedicate with antihistamine, corticosteroids, H2 antagonist
- 3A4
- combo with prednisone
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Ixabepilone -- Ixempra
- binds to beta-tubulin and suppresses instability that leads to mitotic phase -- no cell division
- dosing based on skin surface area
- 3A4
- Cardiotoxic
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eribulin -- Halaven
- metastatic breast cancer
- microtubule dynamics inhibitor
- nontaxoid, from marine sponge
- No CYP
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Antitumor Antibiotics
- intercalation -- cytotoxic
- not cell cycle specific
- not for treating infections
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Antitumor Antibiotics -- classes
- anthracyclines
- bleomycin
- plicamycin
- mitomycin
- dactinomycin
- anthacenediones
- enediynes
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doxorubicin
- anthracycline -- intercalating agent
- pee and sweat bright red color
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anthracyclines moa and info
- non-specific cell cycle drugs with max. toxicity in S and G2 phases.
- intercalation prevents DNA replication
- cardiotoxicity
- extreme extravasation
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Bleomycins -- info
- Cu chelating agents
- minimal myelosuppression
- pulmonary fibrosis
- good combo agents
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Bleomycin
- inj for plantar worts
- cell cycle specific G2 and M phases by inhibiting DNA replication
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Mitomycin -- Mitosol
- prodrug
- inhibits DNA synthesis via crosslinking guanine and cytosine
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dactinomycin -- Cosmegen
- intercalates DNA preventing DNA synthesis, cell cycle non-specific
- prevent extravasation
- natural product
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Mitoxantrone
- tx of MS
- intercalates
- severe immunosuppressive
- pee a blue-green color
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Platinum Drugs
- cell cycle nonspecific agent resulting in DNA cross linking
- prodrugs
- marrow suppression
- No Al containing admin sets
- Severe N/V
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Selenomethionine
Reduces nephrotoxicity from Cisplatin
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Procarbazine -- Matulane
inhibits transmethylation of t-RNA by methionine
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Temozolomide -- Temodar
prodrug, producing a potent methylation agent, inhibiting the initiation of transcription
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Hydroxyurea -- Hydrea
- off label tx of sickle cell
- interferes with DNA replicationby inhibiting ribonucleotide reductases
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