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ACE inhibitors (-pril)
Prevents conversion of angiotensin I to II, preventing major vasoconstriction; also has amild diuretic effect R/T aldosterone
for HTN Reduce mortality & improve LV dysfunction in post MI pt.Heart failure
side effect Dry, hacking cough; orthostatic hypotension
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Adenosine
- “chemical defibrillator,” interrupts or slowsrapid, chaotic electrical conduction pathways; asystole 10-15 seconds
- For Convert SVT to sinus rhythm
side effects Flushing, chest pain, asystole, near death experience
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Antiarrhythmic
- FOR Ventricular tachycardia/fibrillationAlso used with A-fib
- Side effect Hypotension
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Aspirin
Blocks platelet aggregation
FOR ACS given to anyone with S/S of angina/ischemic injuryReduces mortality
Side effect Bleeding precaution
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Atropine
- Parasympatholytic (increase conduction & thus HR by inhibiting acetylcholine)
- For
Primary drug used for symptomatic bradycardias (SB, junctional, heart blocks, idioventricular)AsystolePEA
Side effect Dry mouth, urinary retention, tachycardia, dilates pupils
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Beta blockers (-lol)Propanolol (Inderal)
Negative inotropicDecreases HR and contractility. Puts the heart muscle to sleepBronchoconstricts
For ACS pts to reduce angina& reduce incident of VFSlow conduction in SVTEmergent antihypertensive
Side effect Impotence (*noncompliance issue)
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Calcium Chanel Blockers (CCB)Verapamil Diltizem (Cardizem)
- Relaxes smooth muscle to decrease BP, slows HR via the conduction system suppression
For Slow SVT & rapid atrial fib/flutterAntianginal therapy
Side effect Hypotension, bradycardia, heart block, CHF
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Calcium Chloride
Replaces CaBinds K+
For Known or suspect hyperkalemiaIonized hypocalcemiaAntidote for CCB
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Digoxin (Lanoxin)
- Positive inotropic, negative chronotropic (decreased HR)
For Rapid atrial fibrillation, CHF, SVT
Side effect Decreased HR, Toxicity -N/V, arrhythmiasLoss of appetiteColor changes in field of vision (green halos-textbook)
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Positive inotropic, beta selective (no effect on HR or blood vessels)
For To increase BP in CHF when no shock evident (after fluid therapy)
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Dopamine
Depends on dose:Low- 1-5 mcg/kg/min-renal & messenteric artery vasodilationModerate dose- 5-10 mcg/kg/min—loose the low dose effect instead beta effects (increase HR & contractility) High dose-10-20 mcg/kg/min-beta & alpha effects (vasoconstriction)
For Low dose Renal perfusion(controversial);Mod & High dose Used for hypotensionTo increase HR
Side effect Tachycardia, hypotension, palpitations, sloughing of skin if infiltrates peripherally
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Epinephrine (Adrenaline)
Peripheral vasoconstriction, increase BP & HR
For Cardiac arrest; V-fib/V-tach, asystole, bradycardias & PEA; severe hypotensionAnaphylaxis reaction-bronchospasms
Side effect Can potentiate myocardial ischemia
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Fibrinolytics/Thrombolytics (tPA- Alteplase, Streptokinase)
Dissolves clots Clot buster
FOR AMI <12 hours from onset, Ischemic StrokeHave a window of opportunity Timing is important
Side effects Bleeding anywhere, arrhythmiasMost significant bleeds are intracerebral bleeds because they are life threatening
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Furosemide (Lasix)
Loop diuretic
For Pulmonary edema, HTN, renal or liver disease
Side effect Hypokalemia, dehydration, arrhythmias, decreased BP
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Glycoprotein IIb/IIIa Inhibitor
Inhibit platelet aggregation
For ACS –NonSTEMI or unstable angina possibly with planned PCI
Side effect Recent active bleeding or disorder Thrombocytopenia
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Heparin (unfractionated
Prevent clots from forming
For Prophylaxis and treatment of thrombosis and embolism.
Side effects Contra in recent active bleeding, surgery or bleeding disorders, Heparin Induced Thrombocytopenia (HIT)
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Lovenox (LMWH)
- Prevent clots from forming
For ACS-NonSTEMI or unstable anginaPrevent DVTs
Side effect Hemorrhage is complication
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Lidocaine
Suppresses ventricular arrhythmias by decreasing automaticityNumbs the irritated ventricular electrical cell(s)
For Common drug used to treat ventricular irritability like PVCs, VT, & V-fib
Side effect Toxicity-Neuro changes—drowsiness, disorientation, decreased hearing, slurred speech, heavy tongue, SEIZURES
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Magnesium sulfate—electrolyte
Antiarrhythmic Anticonvulsant
For Treat hypomagnesium which can cause arrhythmias & sudden cardiac deathTx seizures R/T preeclampsia and eclampsia
Side effect Rare toxicity—flushing, sweating mild bradycardia, decreased BP
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Morphine sulfate
Opioid analgesic, vasodilator
For Chest pain
Side effect Hypotension, change in LOC, respiratory depression
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Narcan
Reverse resp depression & sedative effects
For Resp & neuro depression D/T opiate overdose
Side effect May not outlast effect of narcotic Recurrent resp depression
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Nitroglycerin (NTG)
Vasodilator
For Antianginal, MI, HTN, CHF Lowers blood pressure
Side effect Severe headache, hypotension
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Nitroprusside (Nipride)
Peripheral vasodilator
For Lowers blood pressureHTN emergencyReduce afterload in HF
Side effect HA, N/V
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Norepinephrine (Levophed)
For Severe cardiogenic shock or significant hypotension
Side effect Arrhythmia
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Oxygen
Enrich blood with O2
For Any emergency, SOB, CP, stroke or hypoxemia
Side effect Caution in COPD pts D/T hypoxic resp drive
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Plavix (Clopidogrel)
Platelet aggregation inhibitor
For Decreases risk of strokes, MIs and vessel occlusions (stents)
Side effect Bleeding precautions
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Sodium bicarbonate—electrolyte
Alkaline agent
For Management of metabolic acidosisHyperkalemia
Side effect Edema, sodium & water retention, alkalosis, hypernatremia, hypokalemia
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Vasopressin
Potent vasoconstrictorAlso an antidiuretic hormone
For VF, asystole, PEA, septic shockDiabetes InsipidusGI bleeding/varicies
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