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kyleannkelsey
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What type of drug can be delivered directly via intracerebral injection, via systems that utilize brain vessel pH or via food or supplements?
Endogenous neurotransmitters
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What is a Pulse delivery system?
- A delivery system made or erodible polymers
- Each layer of polymer has a different drug loads
- The drug is released during a skin pore opening electric pulse
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What are Hydrogels?
Three dimensional crosslinked networks of homopolymers, copolymers or macromers
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What is the term for a three dimensional, cross-linked network formed from hydrophilic monomers, homopolymers or macromers?
A hydrogel
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Hydrogels can be designed to accept different simuli (T/F)?
- True
- They can accept stimuli from:
- pH, ionic strength, Chemical species, Enzyme-substrates, magnetic, thermal, electrical and Ultrasound irradiation
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What type of drug delivery system can be designed to accept stimuli from pH, ions, Chemical agents, Enzyme-substrate interactions, Magnetic fields, Heat, Electricity and ultrasound irradiation?
Hydrogels
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What is diffusion?
A process of mass transfer via random Brownian motion
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What is the process of mass transfer via random Brownian motion called?
Diffusion
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Perfume, Osmosis and Dialysis are all systems that are based on what basic principal?
Diffusion
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What four reasons were given in class for the importance of diffusion to pharmacy?
- Dissolution of drugs
- Dialysis
- Lyophylization
- Ultra-filtration
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What is the equation for Fick’s law of diffusion or Flux?
- J = dM/(S x dt)
- M = grams of material passing over the barrier in time t
- S = cross-section area of barrier
- J = flux
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What is Fick’s first law of diffusion?
- J = -D (dC/dx)
- D = diffusion coefficient of the solute (in cm2/sec)
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The Diffusion coefficient of Fick’s first law is a function of what five properties?
- Temp
- Pressure
- Conc.
- Solvent properties
- Chemical nature of solute
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What is Fick’s second law?
- D = diffusion coefficient of the solute in cm2/sec
- t = time
- x = position in barrier
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What five important applications for Fick’s laws were discussed?
- 1.) Development of controlled-release dosage forms
- 2.) Bioavailability of dosage form
- 3.) lyophilization
- 4.) Efficiency of dialysis membranes
- 5.) Physiological phenomena (lung gas exchange, renal filtering)
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What equation would you use to predict the bioavailability of a drug via its diffusion coefficient?
Fick’s law
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What equation would you primarily use to calculate the diffusion coefficient?
- tL = lag-time
- h = thickness of barrier
- D = diffusion coefficient
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