Home
Flashcards
Preview
PHA 327 - Exam 2 - Tablets 2
Home
Get App
Take Quiz
Create
What concentration of Starch USP should be used to creating a disintegrating action?
5-20%
What disintegrating agents should be added at a concentration of 5-15%?
Starch 1500
Microcrystalline Cellulose
Alginic Acid
What disintegrating agent should be used at a concentration of 5-20%?
Starch USP
What disintegrating agent should be used at a concentration of 5-10%?
Methylcellulose, Sodium Carboxymethylcellulose
What concentration should Sodium carboxymethyl cellulose and Methylcellulose be used at?
5-10%
What disintegrating agent should be used at a concentration of 2-8%?
Guar Gum
What concentration should Guar Gum be used at?
2-8%
What are glidants?
Substances used to reduce friction between the particles in a dosage form to improve the flow properties
What is the term for substances used to reduce friction between the particles in a dosage form to improve the flow properties?
Glidants
What are anti-adherents?
Substances that are meant to reduce adhesion of the granules to the punch faces and dies
What is the term for substances that are meant to reduce adhesion of the granules to the punch faces and dies?
Anti-adherents
What are lubricants used for in tablet manufacturing?
Reduce friction between the tablet and the walls of the die cavity
What can you use to reduce friction between the tablet and the walls of the die cavity?
Lubricants
How can flavorings be incorporated into tablets?
By spraying dry granules with alcoholic solutions
OR
Incorporated into the lubricant
What forms are flavoring agents available in?
oils
spray dried beadlets
What machine is used to compress tablets?
Tablet press
What are the five components of a tablet press?
Hopper
Feed frame
Dies
Punches
Cams
What does the hopper of a tablet press do?
Stores materials that will be compressed
What part of the tablet press stores materials that will be compressed?
Hopper
What part of the tablet press distributes materials into the dies?
Feed frame
What does the feed frame of a tablet press do?
Distributes materials into the dies
What part of the tablet press control the size and shape of the tablet ?
Dies
What does the Dies of a tablet press do?
Control the size and shape of the tablet
What does the punches of a tablet press do?
Compact the materials within the dies
What part of the tablet press compacts the materials within the dies?
Punches
What does the Cams of a tablet press do?
Guide the punches
What part of the tablet press guides the punches?
Cams
Describe the three very basic steps in tablet pressing as described in class:
1.) Powders fed into the dies
2.) Powders compressed between punches
3.) Tablets ejected from the dies
Describe a rotary tablet press:
Compression rolls move over upper and lower punches compressing tablets in the dies
What three methods are available for making the tablet granulation for compressed tablets?
Direct compression
Dry granulation
Wet granulation
What is the purpose of the wet and dry granulation processes?
To improve the flow of and compressibility of powders that would otherwise be unsuitable for compression
What ways can you improve the flow and compressibility of powders that would otherwise be unsuitable for tablet compression?
Wet and dry granulation
Describe direct granulation:
process of compression of mixed powders into a tablet without intermediate granulation steps
Name the five direct compression diluents discussed in class:
Lactose (spray dies lactose)
Microcrystalline cellulose
calcium sulfate
dibasic calcium phosphate
starch 1500
What are the advantages of direct compression?
Less expensive
No heat or moisture used
Increased surface area for rapid dissolution
More stable tablets
Author
kyleannkelsey
ID
214535
Card Set
PHA 327 - Exam 2 - Tablets 2
Description
PHA 327 - Exam 2 - Tablets 2
Updated
2013-04-19T21:44:46Z
Show Answers
Home
Flashcards
Preview