-
Why is membrane permeability important to performulation?
To determine the biologic response
-
What is the output and properties detected with X-ray diffraction (XRPD)?
- Diffractogram
- Crystallographic properties
-
What is the output and properties detected with IR?
- IR spectrum
- Chemical information
-
What is the output and properties detected with Raman spectroscopy?
- Raman spectrum
- Chemical information
-
What is the output and properties detected with Differential scanning calorimetry (DSC)?
- output = Heat flow versus temperature
- Properties detected = Thermal events
-
What is the output and properties detected with Thermogravimetry (TG)?
- Output= Change in mass vs. temperature
- Properties = Solvate hydrate studies, Degradation
-
What is the output and properties detected with Microscopy?
- Output = Microscopy under light or electron radiation
- Properties = Morphology , Surface examination
-
X-ray diffraction will be the same for two different polymorphs (T/F)?
False
-
What five types of stability were discussed in class?
- Physical
- Chemical
- Microbial
- Therapeutic
- Toxicological
-
Describe physical stability:
The stability of appearance, palatability, color uniformity, etc. until expiry
-
Describe toxicological stability:
No significant increase in toxic effects prior to exipry
-
What four means of enhancing stability were discussed in class?
- Antioxidants
- Preservatives
- Chelating agents
- Buffering agents
-
Name the four mechanism of degradation discussed in class:
- Hydrolysis
- Solvolysis
- Oxidation
- Photolysis
-
What is an accelerated stability test?
One with exaggerated conditions of temp, humidity, light, etc.
-
What conditions are controlled for general stability testing during drug development?
-
What characteristics of the drug are monitored during stability testing (as discussed in class)?
- physical changes (color, odor, taste, texture)
- Chemical changes = drug degradation
|
|