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Name the general MOA of anti seizure drugs
- 1. decrease neuron excitability
- 2. increase seizure threshold
- 3. block abnormal nerve stimulus
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What are the general AE of anti-seizure drugs
drowsy, nausea, vomiting, lethargy, Stevens-Johnsons-Syndrome, lupus erythemat, headache, dysrhythmias, bone marrow suppression (anemia, usually WBC)
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T/F: are you allowed to take antiseizure drugs with meals?
TRUE: as long as it is not crushed and taken at the same time everyday
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Which antiseizure drugs cause HTN and dysrhythmias if given IV too fast?
- phenytoin and fosphenytoin
- *phenytoin is in both drug names
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As a LPN what are you monitoring in pts taking antiseizure drugs?
signs of infection, hypotension, pulse, respiration, IV site
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What are some pt edu points for antiseizure drugs?
drugs will make you drowsy - avoid driving and operating heavy machinery, teratogenic, no alcohol, medic bracelet, med adherance
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Name the anticonvulsant drugs that depress the CNS
- Diazepam (Valium) - bradycardia, cardiovascular collaspe, possible dependence
- Phenobarbital (Solfoton) - decrease respiration, bradycardia, apena, angio edema, SJS
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name the anticonvulsant drugs that stops seizures by alterin the exchange of Na ions
- Phenytonin (Dilantin) - IV, WBC anemias, Hepatitis, hypotension, SJS
- Carbamazepine (Tegretol) - increases seizures, heart failure, anemia, SJS
- Topiramate (Topamax) - leukopenia, tremor, taxia, metabolic acidosis
- Ethosuximide (Zarontin) - leukopenia, lupus, SJS,
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Name the anticonculsant drugs that stop seizures by increasing GABA
- Valporate (Depakene) - pancreatitis, hemorrhage, hepatoxicity, SJS
- Tiagabine (Gabitril) - ataxia, leukopenia
- Felbamate (Felbatol) - hepatic failure, ataxia, tremors, visual disturbances
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