According to Dr. Morgentaler, the bottom line is that if a man has symptoms of low T but there is a discrepancy between his test results of total T and free T he does not have low T.
False
Dr. Morgentaler feels that testosterone therapy in males who have not been castrated or placed on estrogen therapy is unsafe because it can cause prostate cancer.
False
Equilibrium Dialysis is not frequently used to calculate free T for which of the following reasons
it requires a lot of human labor
it takes more time to complete than other tests
it is not effective
According to Dr. Morgentaler, the hallmark symptom of low T
Low Libidio
What effect does testosterone have on bone density?
increases bone density
The majority of physicians use equilibrium dialysis looking at free testosterone to determine low T
False
Dr. Morgentaler uses which of the following methods as his primary test to determine if someone has low T
analog Free T (RIA)
The original Huggins paper from 1941 linking growth of prostate cancer to testosterone therapy was a randomized, double-blind, placebo controlled study evaluating 132 patients.
False
Although the authors of the Endocrine Society Guidelines in 2006 recognized that it is impossible to find a single T value that would reliably seperate men without symptoms of low T from men with symptoms of low T they were consistent with the FDA guidelines, setting the threshold for for low total testosterone at_____.
<300ng/dl
Select all of the following values that are necessary to calculate free T
total testosterone
SHBG
albumin
When using equilibrium dialysis or calculated free T to determine free T, a value below _____ would be considered low.
50 pg/ml
Dr Morgentaler says that when he uses gels he often has to double the dose from 5-10g. What does he say prevents him from using a higher dose?
the patient runs out of skin surface area to rub it in
Please select all of the responses below that Dr Morgentaler sites as positive attributes of Testopel.
Testopel maintains good levels of testosterone for 3-6 months
insertion is a painless in-office procedure under local anesthetic that only takes a few minutes
many patients prefer the idea of Testopel insertion a few times a year compared to injections every 2 weeks
some men prefer a simplified morning routine that does not include several minutes of rubbing a gel into their skin everyday
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According to Dr. Morgentaler, when using the analog free T (RIA) test, concentrations below ____ would be considered low.
15 pg/ml
LHRH (aka GNRH)is released by the ___________. This causes LH (luteinizing hormone) to be released from the ___________ into the blood stream which in turn causes the increased production of testosterone.
hypothalamus, pituitary gland
Dr. Morgentaler feels that when looking at Total T, concentrations of less than 400 ng/dl are suspicious, less than 350 ng/dl are highly suggestive, and less than 300 ng/dl are definitely low
True
All of the following are non-sexual symptoms of low T except _____
low energy/fatigue
increased blood pressure
moodiness
decrease in muscle mass
accumulation of fat
increased blood pressure
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Dr Morgentaler feels that erythrocytosis (aka polycythemia) is a real risk of T therapy and for this reason, hematocrit or hemoglobin should be checked how often?
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At least 2x during first year of T therapy and at least once a year thereafter
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