RV valves open sooner and close later due to differences in electrical activation and pressures
Pulmonary artery valve closure becomes longer during breathing-get splitting of the second heart sounds
Cardiac Output
CO=HR*SV
=HR*(EDV-ESV)
Preload/EDV depends on HR (time for filling), muscle movment (increased venous return), blood volume and blood pressure (eg position could be a factor)
Afterload/ESV modulated by length of cardiac myocytes and inotropic state of the heart (Can be effected by HR due to changes in Ca2+ balance)
HR effects on CO
Acts directly and indirectly via determinants of SV-particularly preload and inotropic state