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MIC 541-Exam 4- Antimicrobials VI-2
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What kinds of resistance can occur against inhibitors of protein synthesis?
Ribosomal changes
Reduced drug accumulation
Modifying enzymes
What inhibitors of protein synthesis can be deterred with modifying enzymes?
Chloramphenicl and Macrolides
What is the usual administration for tetracyclines?
Oral
What is the general spectrum for tetracycline?
Broad
What are important organisms which Tetracycline are active against?
Mycoplasma
Rickettsia
Chlamydia
What disease are Tetracyclines used to treat?
syphilis in penicillin-allergic patients
Syphilis in penicillin allergic patients is treated with what group of antibiotics?
Tetracyclines
What physical feature do Tetracyclines have?
Four rings structures
What is the length of time that Tetracycline act?
Short acting
What way can tetracycline be administered?
PO, IM and IV
What are the long acting Tetracyclines?
Doxycycline
Minocycline
Minocyclin and Doxycycline are in what group of Tetracyclines?
Long acting
What is the mechanism of action for Tetracycline?
They inhibit protein synthesis
Block tRNA to A-site
What are problems with tetracyclines?
it stunts skeletal development in the fetus
Causes tooth staining
May accelerate sunburn
Why do you not give tetracyclines to pregnant women?
abnormal bone development
What group of drugs may cause accelerated sunburn, stunted bone growth and stained teeth?
Tetracyclines
Who do you never give tetracyclines to?
Pregnant women
What happens if you give newborn babies tetracyclines?
Tooth staining and brown bones
What age is safe for Tetracycline use?
Post puberty
What antibiotic should you not give until after puberty?
Tetracycline
What macrolides are available?
Erythromycin
Clarithromycin
Azithromycin
Clarithromycin, Azithromycin and Erthyromycin all belong to what group?
Macrolides
All Macrolides can be give n IV and PO except________________which is only given PO.
Clarithromycin
What are Macrolides used for?
Streptococcal Respiratory infections in penicillin allergic patients
What inhibitor of protein synthesis is used to treat streptococcal respiratory infections in penicillin allergic patients?
Macrolides
Are macrolides drugs used to treat cell wall deficient bacteria?
Yes
What bacteria can be treated with Macrolides (as discussed in class)?
Mycoplasma
Legionella
Less severe Stphylococcal infections
Strep
What are the side effects of Macrolides?
Generally well tolerated and safe
What is the mechanism of action for Erythromycin?
IT IS BACTERIOSTATIC
Blocks polypeptide elongation
What should you not use in combination with a bacteriostatic drug?
A growth dependant drug (penicillin/cephalosporin)
Bacteriostatic drugs can antagonize what other type of drugs?
Bactericidal
What macrolide blocks polypeptide elongation?
Erythromycin
What is the general antibiotic effect of Erythromycin?
BACTERIOSTATIC
What are the safest Erythromycins available?
Esters and Sterate salts
What Protein synthesis inhibitor is best used in the ester and sterate salt forms?
Erythromycin
Author
kyleannkelsey
ID
213565
Card Set
MIC 541-Exam 4- Antimicrobials VI-2
Description
MIC 541-Exam 4- Antimicrobials VI-2
Updated
2013-04-15T02:31:16Z
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