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MIC 541-Exam 4- Antimicrobials IV-4
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Augmentin is used for what mainly?
Ear infections (Daycares/small children)
Clavulanate causes what side effect?
Increased GI activity (causes diarrhea)
Clavulanate induces what?
Causes organism to produce higher levels of B-lactamase that it does not inhibit
Zosyn is used rarely (T/F)?
True
False
False, it is used commonly in hospitals for serious infections
Zosyn has many issues of resistance?
True
False
False
What B-lactamases are controlle with B-latamse inhibitors?
B-lactamses of:
Staphylococci
Hsemophilus
N. gonorrhoeae
many of Enterobacteriaceae
B-lactamase inhibitors are effective against all B-lactamases (T/F)?
True
False
False
What are no B-lactamse inhibitors active against?
Amp-C beta-lactamases
What antibiotic is used for bite wounds?
Augmentin
What aspect of inhibitor combinations is not ideal?
dissimilar pharmacokinetics
Why are pharmacokinetics important to inhibitor combinations?
One need not be excreted before the other
What is a superinfection?
Destruction of normal flora allowing for resistant strains to proliferate
Under what conditions would you develop a superinfection?
High doses of Penicillins
Superinfections are common (T/F)?
True
False
False
What were the tree rare adverse effects discussed in class for Penicillin?
CNS toxicity
Hematologic issues
Hepatic issues
What percent of the population is allergic to Penicillins?
1%
How are severe allergic reactions to penicillins treated?
With epinephrine injection
Cephalosporins are different from Penicillins how?
They have a six membered ring attached to the B-lactam ring (not five) and several substituents
Why are there more options for chemically altering Chephalosporins that Penicillins?
There are more substituents
Why are there more Cephalosporins than penicillins?
More substituents to alter
Methoxy group attached to the B-lactam ring indicates what type of B-lactam?
Cephamycins
What is the difference between Cephalosporins and Cephamycins?
Produced by different organisms
Cephamycins have a methoxy group attached to the B-lactam ring
Carbacephems are in what group?
Cephalosporins
Cephalosporins and Cephamycin are as good as Penicillin (T/F)?
No
Cephalosporins are grouped in what way?
By generations
What are examples of 1st generation cephaolsporins?
Cefazolin
Cefaclor
What characteristic was noted in class about 1st generation cephalosporins?
Relatively narrow spectrum
What group of cephalosporins are relatively narrow spectrum?
1st generation
What characteristics in class were noted about 2nd generation cephalosporins?
They are of intermediate spectrum
What is an example of a 2nd generation cephalosporin?
Cefuroxime
What characteristic was noted in class about 3rd generation cephalosporins?
Broader spectrum with some Pseudomonas activity
What is an example of a 3rd generation cephalosporin?
Ceftazidime
What is characteristic of a 4th generation cephalosporin?
broader spectrum
more resistant to chromosomally mediated B-lactimases
What is an example of a 4th generation cephalosporin?
Cephepime
What generation of cephalosporins are of intermediate spectrum?
2nd generation
what generation of cephaolosporins of a broader spectrum and hae some pseudomonas activity?
3rd generation
What generation of Cephalosporins are of a broader spectrum and are more resistant to chromosomally mediated b-lactamases?
4th generation
What generation of cephalosporins does Cefazolin and cefaclor belong to?
First generation
What generation of cephalosporins does cefuroxime belong to?
2nd generation
What generation of cephalosporins does ceftazidime belong to?
3rd generation
What generation of cephalosporins does cefepime belong to?
4th generation
Ceftazidime has good activity against what particular bacteria?
Pseudomonas
There is cross-allergy between what two antibiotic groups?
Penicillins and Cephilosporins (5-15%)
What rate of cross-allergy is there between Penicillins and cephalosporins?
5-15%
A person with a penicillin allergy has a 5-15% chance of having an allergy to what other antibiotics?
Cephalosporins
What options do you have if you have a patient with a severe penicillin reaction, what alternate options do you have?
Give a cephalosporin (if you need a cidal drug)
Use a non-beta-lactamase drug
Under what conditions would you use a non-betalactamase drug or use cephalosporins only if you need a cidal antibiotic?
If the patient has had a severe penicillin reaction
How long after administration will a life threatening reaction to a cephalosporin is going to occur?
30 minutes
In what time frame will a cross-allergy to cephalosporin occur?
Later than 30 minutes
Penicillin reactions are mediated with what antibody type?
IgE
What should you do if you need to give a patient a cephalosporin who has a serious penicillin allergy?
Wait 30 minutes with the patient with epinephrine and tracheostomy tube
Under what conditions would you site with a patient with a tracheostomy tube and epinephrine for 30 minutes?
Giving a cephalosporin to a patient with a sever penicillin allergy
Allergic reactions to cephalosporins that occur much later are or are not life-threatening?
not- life threatenting
What way can you administer a cephalosporin to a patient with a penicillin allergy to minimize the reaction?
Give them a quarter dose first
What administration routes are available for Cephalosporins?
Oral
Parenteral
Author
kyleannkelsey
ID
213464
Card Set
MIC 541-Exam 4- Antimicrobials IV-4
Description
MIC 541-Exam 4- Antimicrobials IV-4
Updated
2013-04-14T21:03:48Z
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