-
Definition of ASH
Total mineral count in a food
-
How do you determine ASH?
- Refers to the noncombustible residue remaining after a measured sample of food is burned at 600 C for 120 minutes. The amount of ash is determined by calculating the residue as a percentage of the original sample.
- Ex: 50 g sample, ash is 3.5 g, percent is 7%.
-
Ash contains what essential minerals?
Calcium, phosphorus, salt and iron
-
Excessive ash content has been implicated in
- FUS (feline urological syndrome)
- FIUTD (Feline lower urinary tract disease)
-
Calcium & Phosphorus are necessary for
- normal bone development
- provide rigidity for bones and teeth
- aid in blood coagulation
- necessary for nerve excitability
-
What is the proper ratio of calcium and phosphorus is necessary to achieve normal growth and development?
1.2 to 2 parts calcium to each part phosphorus
-
Calcium & Phosphorus are important in what situtations?
You must wait until __________ before supplementing calcium
- young (growing), geriatric, trauma (remodeling bones)
- lactating
-
Bone is composed of a bone matrix containing
calcium, phosphorus, carbonate, citrate, magnesium, sodium, potassium, chloride, fluoride and trace elements
-
Define Cartilage
Elastic semi-hard tissue covering the surface of the bone that permits smooth motion and diminishes friction
-
Define epiphysis
a temporary cartilage formation which grows by multiplying its own cells. This is the main point of bone growth.
-
When growth is complete the epiphyseal junction is replaced by calcified bone. This
occurs at about ______ and is called the
- 1 yr old
- "closing of the epiphysis"
-
Epiphysis closes on Cats & small dogs around Large Dogs
- 8-10 months
- 1 - 2 yrs old
-
Phosphorus from animal sources is ____ while phosphorus from plant sources is _____.
-
What is an excellent source of calcium and phosphorus to pets
Bone meal
-
Nutritional Secondary Hyperparathyroidism (NSH) results in
a softening or deformation of bones due to failure of the bone matrix to solidify.
-
List the disease associated with animals who are fed an all meat diet during their growth stage which results in weight-bearing skeletal deformities and folding or compression fractures.
Nutritional Secondary Hyperparathyroidism
-
Nutritional Secondary Hyperparathyroidism (NSH) occurs in what animals?
What are the results?
- animals who are fed an all meat diet during their growth stage.
- results in weight-bearing skeletal deformities and folding or compression fractures.
-
List the disease that affects young, rapidly growing large or giant breed dogs with symptoms of soft tissue swelling around the distal radius, ulna and tibia.
Hypertrophic Osteodystrophy
-
Hypertrophic Osteodystrophy
Affects:
Symptoms:
- Affects: young, rapidly growing large or giant breed dogs
- Symptoms: pain, soft tissue swelling around the distal radius, ulna and tibia, lameness, varying degrees of fever, lethargy, and anorexia.
-
List the condition associated with a small acetabulum, a misshapen femoral head that results in lameness and pain in the joint.
Canine Hip Dysplasia
-
Canine Hip Dysplasia –
Thought to be a genetic problem manifested by
Symptoms:
- a small acetabulum, a misshapen femoral head.
- Symptoms: lameness and pain in the joint.
-
What organization screens and rates hip dysplasia?
OFA (Orthopedic Foundation for Animals)
-
What breed of dog has the most occurrences of Hip dysplasia?
English Bulldogs
-
List the disease that affects pen-fed young bulls with symptoms of sudden lameness and atrophy of the hip and hind limb muscles
Degenerative Joint Disease
-
Degenerative Joint Disease
Affects:
Symptoms:
Thought to be _____ but can be made worse by a diet ____ in phosphorous and ___in calcium
- Affects: pen-fed young bulls
- Symptoms:Sudden onset of lameness, atrophy of the muscles of the hip and hind limb.
- hereditary; high; low
-
Rickets (Osteomalacia)
Affects:
Cause:
- Affects: young growing animals
- Cause: a deficiency in phosphorus and Vitamin D
-
List 2 diseases associated with soft bones
- Nutritional Secondary to Hyperparathyroidism
- Rickets
-
Define Parturient Paresis
Calcium deficiency at the time of birth
-
List 2 diseases associated with cattle following calving.
Symptom:
- Hypocalcemia and hypophosphatemia
- Symptom: Inability to rise
-
List the disease associated with calcium deficiency in dogs at time of birth
Eclampsia - Gradual decrease of calcium over time
-
List the disease associated with calcium deficiency in Mares at time of birth
Lactation Tetany
-
Treatment for Parturient Paresis is
If treatment listed doesn't work it could be
- Oral calcium paste, IV calcium; Calcium supplements.
- obturator nerve paralysis
-
List 3 Hormonal Influences on Calcium and Phosphorus Absorption
- Parathyroid Hormone
- Calcitonin
- Vitamin D
-
Parathyroid Hormone (PTH) is produced by the parathyroid gland and is necessary for
moving calcium from bone. Prevents having continual bone growth.
-
Calcitonin is produced by the ______ and it inhibits _____________.
- thyroid gland
- bone resorption
-
Vitamin D - appears to function more as a _____ than a vitamin.
Promotes:
Sources of Vit D:
- hormone
- Promotes: intestinal calcium absorption.
- Sources of Vit D: milk, sun, dairy products
-
Calcium absorption occurs in the
small intestine, mainly the duodenum and the jejunum.
-
Magnesium is used in many fundamental ___________, especially the use of _______ and _______ for energy
- enzymatic reactions
- amino acids
- fatty acids
-
Magnesium absorption occurs in the
small intestine
-
What affects magnesium absorption?
- A. Calcium
- B. Phosphorus
- C. Calcitonin
- D. Parathyroid hormone
-
List the deficiency associated with puppies that causes depression, incoordination & muscular weakness, hyperextension and droopiness of the ears and tail.
Magnesium
-
Magnesium deficiencies in puppies has been shown to cause:
- A. Depression
- B. incoordination and muscular weakness
- C. hyperextension (walking on carpal joints)
- D. droopiness of the ears and tail.
-
What might affect magnesium deficiency?
Not being absorbed through the food
-
List the deficiency that is associated with cats that causes muscular weakness, hyperirritability, convulsions, reduced food intake and poor growth.
Magnesium
-
Magnesium deficiency in cats exhibited:
- A. muscular weakness
- B. hyperirritability
- C. convulsions
- D. reduced food intake and poor growth.
-
FLUTD
Affects:
Signs:
- Affects: young cats (most affected), male cats and overweight.
- Signs:
- A. Increase use of the litterbox without much
- urine production
- B. Vomiting
- C. Less interest in food
- D. Signs of discomfort
-
FLUTD
Diagnosis:
Treatment:
Preventative measures:
- Diagnosis: Urinalysis, Blood Panel, may possibily do a urinary culture, abdominal ultrasound, x-rays
- Treatment: SQ Fluid therapy, prophylactic antibiotics, dietary therapy – canned food. Cat with complete urinary obstruction treatment includes placement of a urinary catheter to release the obstruction.
- Preventative measures: Dietary therapy (canned food – low in ash), fluids, drink more water.
-
If a cat has had FUS/FLUTD 4 or more times they may perform a
perineal urethrostomy
-
Hip Dysplasia in dogs
Symptoms:
Diagnosis:
- Symptoms: pain, lameness, change in activity level
- Diagnosis: By physical exam to detect loosens of the hip by palpation, x-rays .
-
Hip Dysplasia
Treatment:
Phase 1 – Age __________ to ______
Treatment
- 7 months to 1 year
- Nonsteroidal anti-inflammatory drugs (NSAID’S) to relive pain;
- Nutraceuticals (Chondroitin, Glucosamine) which may help to restore cartilage and reduce pain
- Injectable agents (Adequan) may help to reduce wearing of cartilage
- Cortisone may help with pain but there are many side effects
- Dietary management – weight loss or dietary restriction.
-
Hip Dysplasia
Surgical Treatment:
Preventative surgeries:
- Surgical Treatment: Total hip replacement (THR); Femoral head resection. A less common option is hip deinnervation where remove sensation from the hip
- Preventative surgeries: Triple Pelvic Osteotomy; Juvenile Pubic Symphysiodesis (preformed on young pups to prevent hip dysplasia
-
Hip Dysplasia is common in what breeds?
German Shepherds, Golden Retriever, Rottweiler, Pugs.
-
Hypomagnesemia AKA
Occurs in:
Signs:
Treatment:
- Grass Tetany, Grass Staggers)
- Occurs in: the spring of the year - Cattle tend to top off grass where Mg levels are low at the top. If grass has been heavily fertilized with a nitrogen fertilizer this will also inhibit mg absorption by the cow. Also occurs in calves who fed a strictly milk diet.
- Signs: ataxic, possible seizures, coma, death.
- Treatment: salt lick may cause the cow to drink more water.
-
List the minerals that serve as fluid regulators
Sodium, potassium and chloride
-
SODIUM, CHLORIDE & POTASSIUM are necessary minerals that serve as _______. They help to maintain the _______________. These are commonly known as __________.
- fluid regulators
- balance between fluids inside and outside of the cell
- electrolytes
-
Fluid normally given in emergency situations is
Another common electrolyte that can be given is
- Lactated ringer's solution (LRS)
- Gatorade or Pedialyte
-
Function of Sodium
Excess sodium is excreted by the
- Essential element of plasma and other extracellular fluids.
- Aids in the transfer of nutrients and the removal of waste from the cells.
- Produces bile which is important in the digestion of fats and carbohydrates.
- Kidney
-
Function of Chloride
Chloride is excreted in the
- Needed for the formation of hydrochloric acid in the gastric juices, which is used to digest protein
- urine
-
Causes of Sodium Chloride NaCl deficiency:
- Prolonged and severe diarrhea
- Vomiting
- Adrenal cortical insufficiency.
-
Fatigue, exhaustion, inability to maintain water balance, decreased water intake, retarded growth, dryness of skin are signs of what deficiency
Sodium Chloride
-
Signs of NaCl deficiency are
- fatigue
- exhaustion
- inability to maintain water balance
- decreased water intake
- retarded growth
- dryness of skin
- loss of hair
-
Excess Sodium Chloride can occur with _____
Signs:
- water deprivation
- thirst, pruritis, constipation, anorexia, seizures, and death.
-
Function of Potassium
Potassium is absorbed in the
- Needed for proper enzyme, muscle, nerve function, fluid balance and appetite.
- Small and large intestine.
-
Poor growth, restlessness, muscular paralysis, cramping, dehydration, lesions in the heart and kidney are signs of what deficiency?
Potassium
-
Signs of Potassium deficiency include
- poor growth
- restlessness
- muscular paralysis
- cramping
- dehydration
- lesions in the heart and kidney
-
Causes of Potassium deficiency:
High levels of potassium have been known to affect the absorption of
- chronic diarrhea, vomiting, starvation or diabetes mellitus.
- magnesium
-
Short term potassium deficiency through vomiting and diarrhea may be caused by
parvo
-
Iron combined with large protein molecule makes _________, which is iron containing compound in ___________.
Iron is needed in
- hemoglobin
- red blood cells
- transporting oxygen and for enzyme in energy utilization
-
Iron is absorbed in the ___________.
Absorption is rapid, appearing in the red blood cells in about __________ after ingestion.
- small intestine
- four hours
-
Define hemopoiesis
The formation of RBCs and the largest utilization of iron
-
Define Blood
a mixture of cells suspended in plasma
-
Plasma is made up of mostly water but also contains
proteins, sugars, hormones and salts.
-
Erythrocytes (RBCs)
make up _______% of RBCs
Function:
Lifespan:
Bone marrow produces ____ RBCs every ____
to replenish the ones that wear out
- 40-45%
- Function: carry oxygen to other cells of the body and to take away CO2 as a waste product.
- Lifespan: 4 months.
- 4-5 billion; hour
-
Leukocytes (WBCs)
Function:
Bodies defense system fights infections from bacteria and viruses.
-
Define Thrombocytes (platelets)
Function: to plug holes in the vessels walls. It slows the loss of blood within _____. The plug
lasts ________ until the platelets run out of energy and fall apart.
- small pieces of material or cytoplasm.
- 3-5 mins
- 24 – 72 hours
-
Define Anemia
Symptoms:
Origin/Cause:
- is an iron deficiency
- Symptoms: reduced appetite, diarrhea, rough hair coat, increases susceptibility to disease.
- Caused by: hereditary, pathology or nutritional origins.
-
Nutritional anemia is more likely to occur in the _______ during the _______________. Milk is extremely ______ in iron source.
-
Sources of Iron
meat, greens, supplements
-
How do we test for anemia?
- PCV %
- Microhematocrit tube (MCHT) fill with blood, put clay stopper, spin in centrifuge for 3 mins. Read to get %
- Chemistry Blood Analyzer to get a more accurate answer
-
Define Aplastic Anemia
Bone marrow fails to produce essential blood elements. Bone marrow doesn’t keep up with RBCs demand. Does not respond to anti-anemia therapies
-
Define Hemolytic Anemia
Caused by shortened lifespan of RBCs and the bone marrows inability to compensate for the decreased lifespan. The body destroys the RBCs
-
Define Hypochromic Anemia
Varying degrees of erythrocytes under development. Pale color. Central pallor is normal in a dog, but abnormal in any other animal.
-
Define Parasitic Anemia
Absence of RBCs due to parasite ingestion, endoparasite or ectoparasites
-
At what PCV level will a transfusion be warranted?
PCV 10-15%
-
PCV or microhematocrit for most animals is
37-45%
-
Normally RBCs are spaced out – in a horse they are stacked on top of each other known as
Rouleaux
-
Why do most commercial pet foods supplement Zinc?
Zinc is considered a
- due to the bodies inability to absorb zinc efficiently
- trace mineral
-
Hypogonadism, skeletal deformities, corneal lesions, impaired immune systems are signs of what deficiency?
Zinc
-
List 4 conditions that may result due to zinc deficiencies
- hypogonadism (small genitales)
- skeletal deformities
- corneal lesions
- impaired immune systems
-
Manganese occurs principally in the body in the
liver, kidney, pancreas, and bones
-
Function of Manganese
- Essential for normal reproduction
- Essential in glucose utilization
- Involved in the production of insulin and prothrombin.
-
What interferes with the absorbtion of manganese?
Excessive calcium and phosphorus
-
Function of Copper
- Used for mobilizing iron for hemoglobin synthesis.
- Used for maturation of collagen, pigmentation of hair, neural transmission
-
Copper Absorption is in the
The primary storage sites are the
- Stomach and upper small intestine
- Liver, kidney and brain
-
Copper deficiencies in cats can result in
Decreased plasma and connective tissue defects in the aorta
-
Copper deficiencies in dogs
Affects what breed:
Signs:
- Affects what breed: Alaskan Malamutes
- Signs: dwarfing and skeletal deformations, which may be hereditary
-
Copper Toxicity
Affects what breed of dogs:
Copper levels are _____in the liver but serum
concentrations are _____.
AKA:
- Affects what breed of dogs: Bedlington terriers, West Highland White, Dobermans, and Cocker Spaniels may also have a genetic predisposition to copper toxicity
- high; low
- AKA: Bedlington terrier copper associated hepatopathy or Copper Storage Disease.
-
Copper deficiency in ruminants
AKA:
Cause:
It has also been recorded in ______
- AKA: Enzootic ataxia, swayback, falling disease.
- Cause: anemia and central nervous system disorder
- pigs
-
Selenium
Found in:
Previously considered a ___, now found to be a ___________.
Appears to be a required _______.
Selenium deficiency appear to be an etiological agent in _______.
Selenium toxicity is characterized by
- Soil
- toxin; required trace mineral
- growth factor
- myopathies
- a garlic like odor to the breath.
-
Dyspnea, frothy nasal discharge, and irregular heart beat are signs of what deficiency?
Selenuim
-
Most common disease associated with selenium deficiency
Affects:
Name:
Signs:
- Affects: calves, lambs and foals.
- Name: White Muscle Disease or enzootic muscular dystropy.
- Signs: dyspnea, frothy nasal discharge, and irregular heart beat. Most will die or if they survive are weak and dyspneic (difficulty breathing)
-
2 diseases associated with selenium diseases in pigs are:
- Mulberry Heart Disease
- Hepatosis dietetica
-
Hepatosis dietetica is a degenerative disease of the liver. There is massive _______ and __________ is the only clinical sign.
- hepatic necrosis
- sudden death
-
Selenium disease in dogs, is relatively uncommon, but if does occur creates a
myocardial necrosis
-
Selenium can be found in high protein sources such as
wheat or soy
-
Selenium toxicity in ruminants is due to
overconsumption
-
Selenium toxicity in ruminants
Symptoms:
Acute toxicity will cause
- Symptoms: Listlessness, hair loss, soreness or sloughing of hooves, lameness, cardiac atrophy.
- Acute toxicity will cause blindness, abdominal pain and respiratory arrest.
-
The only known role of iodine is for
These hormones are necessary for
- the synthesis of two hormones produced by the thyroid gland.
- the regulation of cell oxidation
-
Iodine Deficiency in
Cats is associated with
Dogs is associated with
- goiters, alopecia, abnormal calcium metabolism and death
- goiters, skeletal deformities, alopecia, lethargy and timidity
-
Cobalt is a component in
Deficiency is unlikely to occur if it is adequately in diet.
Found in
-
Nickel - No levels have been established for domestic animals.
Food sources:
rice, legumes, oats and most vegetables
-
Sulphur – Occurs in
No levels have been set
amino acids, cystine and methionine.
-
Molybdenum
Important in the formation of
Toxicity signs:
- uric acid
- chronic diarrhea, ill-thrift, depigmentation of the hair
-
Aluminum – Essential to
fertility and immune system
-
Silicon
Important to
An essential
- bone mineralization
- trace element
-
Chromium
Essential to the
May be related to the onset of
- metabolism of carbohydrates
- diabetes mellitus in primates
-
Flourine
Necessary for
Found in
- bones and teeth
- toothpaste and water
-
Fat Soluble Vitamins
A, D, E & K
-
Vitamin A is stored in the _______ as palmitate ester (retinyl palmitate) and it
circulates in the serum as an alcohol (retinol). Vitamin A is absorbed rapidly in the ____.
-
Major source of Vitamin A in nature are Vitamin A precursors, the _________.
The most common being __________ which is yellow pigment in plants
-
The dog utilizes carotene effectively while the cat is unable to do so. Cats rely on stored Vitamin A in
animal and fish oils
-
Vitamin A is involved with
vision and cell mitosis
-
Vitamin D is also called ________, Vit D actually functions as a hormone involved in the regulation of ___________.
- cholecalciferol
- calcium metabolism
-
Vitamin D Toxicity can result in
- depressed growth
- mineralized soft tissues (heart, lung, kidney)
-
Vitamin E is also known as _________.
Found in plants and grains, especially ____________.
Carnivores obtain it from the _____.
- tocopherol
- soybean and wheat germ oils
- liver and adipose tissue
-
In order for Vitamin E to function it must be in the presence of
- polyunsaturated fat
- selenium
- sulfur amino acids
-
Define Steatitis or Pansteatitis
AKA
- inflammation of fatty tissue
- Yellow fat disease
-
Vitamin K helps to activate ___________. Deficiencies are uncommon in most domestic animals, but occurs most often in _______.
- prothrombin
- poultry and cattle
-
Vitamin K sources
Green leafy plants and vegetables (alfalfa, spinach)
-
Coumarin is used today in __________ and __________ in cardiac patients.
- rat poisoning
- anti-coagulation drugs
-
Vitamin C is also known as _________.
Vitamin C is highly soluble in water and readily absorbed from the gut if supplemented. The body manufactures it naturally from _______.
-
Vitamin C is considered essential in what species?
- human primates
- some birds
- guinea pigs
- fish.
-
THIAMIN also known as ____.
Found in
- Vit B1
- cereals and cereal brans mainly but also in meat, legumes, green vegetables, fish, fruits, and milk.
-
What vitamin was found to be the factor that prevented beriberi, a neurological disorder
characterized by weight loss, paralysis, lack of coordination, mental confusion, convulsions and apathy. Heart failure is the most common cause of death from beriberi
Thiamin
-
Riboflavin also known as _____
Found in
- Vit B2
- dairy products and organ meat
-
What vitamin deficiency causes Curled
Toe Paralysis in chickens
Riboflavin
-
Niacin is found in _________.
Essential for normal
- various plant and animal tissues
- carbohydrate metabolism
-
What vitamin deficiency causes Black tongue in dogs characterized by stomatitis, dermatitis, anemia, hemorrhagic diarrhea.
It is called ______ in humans.
-
Pantothenic Acid - Found in _____________
Essential for all animals except the
- all plant and animal tissues
- ruminant which synthesize in the rumen
-
Vitamin B6 is involved in the metabolism of __________
Comes in three forms
___________ has the most nutritional valve.
- amino acids.
- Pyridoxine, pyridoxal and pyridoxamine.
- Pyridoxine
-
Folic Acid is important in __________.
It is involved in the synthesis of
- reproduction
- amino acids and DNA
-
Define Megaloblastic anemia
abnormal RBC production due to folic acid deficiency
-
Megaloblastic anemia is a deficiency of what vitamin?
Folic Acid
-
Biotin also known as ______
Found naturally in most foods. Experimental deficiency in calves caused _______.
-
Choline is synthesized in the ______ from the _______
-
“Perosis” (Chondrodystrophy) deformity of the leg bones in poultry is caused by what vitamin deficiency?
Choline
-
What vitamin deficiency causes night blindness in young animals
Vitamin A
-
What vitamin deficiency causes Rickets in cats and dogs
Vitamin D
-
What vitamin deficiency causes Brown Bowel Syndrome
Vitamin E
-
What toxin and vitamin is associated with Sweet Clover Poisoning
Coumarin blocks the vitamin K in production of prothrombin.
-
What vitamin deficiency causes Scurvy
Vitamin C
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