MIC 541-Exam 4- Antimicrobials II - 1

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What is pharmacokinetics?

Drug interaction with the patient
What is the term for a drug interaction with the patient?

Pharmacokinetics
What is Pharmacodynamics?

Interaction of drug with the targeted bacteria
What term describes the interaction of a drug with the targeted bacteria?

Pharmacodynamics
What does Bacteriostatic mean?

Reversible loss of the ability to reproduce
What is the term for the reversible loss of the ability to reproduce?

Bacteriostatic
What is the definition of Bactericidal?

Irreversible loss of the ability to reproduce
What term describes the irreversible loss of the ability to reproduce?

Bactericidal
What is the post antibiotic effect?

Continuing antibacterial effects after the drug is removed
What term describes the continuing antibacterial effects after a drug is removed?

Post-Antibiotic effect
MICs only measure what component of growth?

Inhibition of visible growth
What do MICs measure?

Inhibition of visible growth (ONLY)
Can MICs be used to qualify the process type for bacterial inhibition (cidal, static, etc?)

No
Can MICs be used to quantify the rate of Killing of an antimicrobial?

No
Can MICs be used to determine inoculum regrowth?

No
What does a growth curve for bacteriostatic activity look like?
- The plateau, where growth just offsets death rates, is lowered.
What does a growth curve for bactericidal activity look like?
- The growth curve decreases rapidly with no plateau
A growth dependent antibacterial has what feature to its bactericidal growth curve?
- The bacteria begin to multiply, followed by an attenuated long slow decrease in number
What does a growth curve for bacteria that are growth independent killers look like?
- The current bacterial level drops at a fairly steep rate. The growth phase is never entered by the bacteria.
Give an example a growth dependent killer:

B-lactam (cell wall active)
Give an example of a growth independent killer:

Flouroquinolone or aminoglycoside
What drug examples were given in class for concentration dependent killing?
- Aminoglycoside
- Flouroquinolone
What does a graph for a concentration dependent killer look like?
- The effect (y) rises as the concentration (x) also rises
- Fairly constant slope
What is an example of a Concentration-independent killer?

Beta-lactams
Describe what a graph for a concentration independent killer looks like:

The effect rises rapidly with the concentration (in a single step) and then the effect plateaus, despite rising concentration