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Fluorouracil (antimetabolite)
5-FU
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Cytoxan (alkylating agents)
NITROGEN MUSTARD
cyclophosphamide
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Leukeran (alkylating agents)
NITROGEN MUSTARD
chlorambucil
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List Nonsteroidal antiandrogens
- Casodex (bicalutamide)
- Eulexin (flutamide)
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CellCept
mycophenolate MMF
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Leucovorin calcium
Folinic acid
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How does 5-FU work
- -metabolized via anabolic pathway--> blocks methylation rxn of dUMP to dTMP-interferes w/synthesis of DNA, inhibits formation of RNA
- -creates a thymidylate deficiency
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What is the counseling for 5-FU?
- avoid SUN - blisters
- avoid eyes - blindness
- wash hands
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How does cytoxan work?
- the activated form phosphoramide mustard, alkylates binds w/intracellular molecular structures
- Cross-links DNA and RNA strands
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Dosage for for 5-FU
- Carac Cream 0.5% -QD X 3 days
- Fluroplex 1% Cream BID X 14 days
- Efudex 5 % Cream BID X 14 days
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Dose for cytoxan
25, 50 mg TABS
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