Home
Flashcards
Preview
pharma II test III thyroid disorders
Home
Get App
Take Quiz
Create
rate limiting step in thyroid hormone formation
sodium/iodide symporter (NIS)
3 ionic inhibitors of NIS
SCN thiocyanate
Clo4 percholate
NO3 nitrate
what stimulates the NIS
TSH
what oxidizes iodide
thyroidal peroxidase
3 inhibitor of thyroidal peroxidase (thioamides)
propylthiouracil - propacil
methmiazole
high concentrations of iodides
what stimulates thyroidal peroxidase
TSH
what is iodide incorporated into and then bound to in the colloid resulting in
tyrosine
thyroglobulin
MIT & DIT
two drugs that block proteolysis and release of T4&T3
lugol's solution
ssKI
how is T4 converted to T3 in he periphery
5' deiodinase
what is T3&4 bound to in the plasma
thyroxine-binding globulin (TBG)
what increases TBG synthesis
estrogens
what decreased TBG synthesis
androgens
starvation
metabolism of thyroxine
deiodination in the liver
4 clinical presentations of hypothyroidism
pale
cold dry skin
brittle hair
bradycardia
3 adverse effects of levothyroxine - synthroid
tachycardia
tremors
hyperthermia
synthetic T4
levothyroxine - synthroid
2 drugs interactions with levothyroxine
enhanced warfarin actions
catecholamines
provides clinical remission with destruction of thyroid gland
radioactive iodine 131
2 things PTU inhibits
thyroid peroxidase
5'deiodinase
3 adverse effects of thioamides
agranulocytosis
hypothyroidism
pregnancy and lactaction
thioamide that blocks only thyroid peroxidase
methimazole
antithyroid agent that would assist in suppressing tachycardia and other symptoms of graves disease
beta blocker - propranolol
used in thyrotoxic crisis
beta blocker - propranolol
which situation is liothyronine preferred over levothyroxine
myxedema coma
addition function you should follow with propylthiouracil therapy
serum white blood cell counts
best reason to choose T4 over T3 Tx
conversion of T4 to T3 allows the body some control over hormone delivert to tissues
Author
tab
ID
212784
Card Set
pharma II test III thyroid disorders
Description
pharma II test III thyroid disorders
Updated
2013-04-11T02:39:31Z
Home
Flashcards
Preview