PTG 105 -Exam 3 -Lecture 21- 2

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  1. What is the cause of Rickets/Osteomalacia
    Poor intake or utilization of Vit. D
  2. What is caused by poor intake or utilization of Vit. D?
    Osteomalacia or Rickets
  3. What serum levels can be used to detect Rickets/OM?
    Low serum phosphate and Ca levels
  4. What are signs of Rickets?
    • Soft spot on head is slow to close
    • bony necklace
    • bowed legs
    • big lumpy joints
    • curved bones
  5. A child that presents with big lumpy joints, curved bones, bowed legs, a slow closing soft spot on the head and a bony necklace is likely to have what disease?
  6. Osteomyelitis is what?
    Infection of the bone
  7. What is the term for infection of the bone?
  8. What are common causes of Osteomyelitis?
    • commonly caused b ypyogenic bacteria like Staph
    • Mycobacteria (TB)
  9. What are the two main types of Osteomyelitis?
    • Hematogenous route
    • Secondary OM
  10. Describe the pathology of Hematogenous Osteomyelitis:
    • Sprad through blood and localizes on bone
    • causes pus formation
    • causes bone necrosis
  11. What are the symptoms of Hematogenous Osteomyelitis?
    Bone pain and swelling
  12. Where is the usual site of entry for Hematogenous Osteomyelitis?
  13. What is the usual infecting bacteria in Hematogenous Osteomyelitis?
    Staph aureus
  14. Describe Secondary Osteomyelits:
    infection spread to bone from adjacent site of infection or open wound
  15. When an infection spread to the bone through an adjacent site or wound, what is it called?
    Secondary Osteomyelitis
  16. Describe Acute Osteomyelitis:
    • Intense neutrophilic inflammation
    • abcess formation
    • drainage of sinuses
    • bone necrosis
  17. Describe Chronic Osteomyelitis:
    • chronic inflammatory cells initiate repair process
    • fibroblastic proliferation
    • residual necrotic bone is called sequestrum
  18. Which pathological type fo OM contains sequestrum?
    Chronic OM
  19. Which pathological type of OM has intense neutorphilic inflammation, abcess formation, draining sinuses and necrotic bone?
    Acute OM
  20. Which type of OM has inflammatory cell intiate repair, fibroblastic proliferation, residual necrotic bone is called sequestrum?
    Chronic OM
  21. What is Pott disease?
    Tuberculosis OM of vertebra
  22. What is the term for Tuberculosis Om of the vertebra?
    Pott disease
  23. Describe Pagets disease:
    Skeletal deformity due to accumulation of excess amount of architectually abnormal bone
  24. What disease is a skeletal deformity where exess amounts of abnormal bine accumulate?
    Paget's disease
  25. PAget's disease etiology is:
    • unknown
    • possibly viral (paramyxomius)
  26. Paget's disease is common in what races and rare in what others?
    • Common in northern european whites
    • Rare in Asia or Africa
  27. What disease has the charcteristic f Mosaic patterns of lamellular bone?
    Paget's disease
  28. Paget's disease has what characteristic bone pattern?
    Mosaic pattern of lamellular bone
  29. Paget's disease is associated with an increaed risk of what other disease?
    Osteosarcoma (malignant bone tumor)
  30. What is another term for malignant bone tumor?
  31. What is the pathogenic effect sof paget's disease?
    marked by bone reabsorption, followed by excessive bone formation
  32. What is another name for Paget's disease?
    osteitis deformans
  33. What bones are commonly affected by Paget's disease?
    Skull, spine, Pelvis, thigh and shin
  34. What is an osteoma?
    Benign bone tumor
  35. Where are Osteomas usally found?
    mature bones, commonly in head or neck
  36. Osteoid Osteoma (Osteoblastoma) is what?
    Benign tumor of the bone (usually femur)
  37. What is the differnce between an Osteoid Osteoma and and Osteoblastoma?
    An Osteoblatoma is greater than 2 cm ad a Osteoid Osteoma is less than 2cm in diamter
  38. What is the occurance of Osteoid Ostoma or Osteoblastoma between men and women?
    M:W 2:1
  39. What bones are involved in Osteiod Osteoma and Osteoblastoma?
    Any bone, 50% are the femur
  40. What age group commonly gets Osteoid Ostoma?
    20s to 30s
  41. Histologically what do Osteoid Osteoma look like?
    Resemble normal bone
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PTG 105 -Exam 3 -Lecture 21- 2
PTG 105 -Exam 3 -Lecture 21- 2
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