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What is Osteosarcoma?
Malignant tumor that produces bone matrix
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What is the new bone called that is produced by the cells of Osteosarcoma?
Malignant Osteoid
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What is the most common primary bone malignancy?
Osteosarcoma
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How does the primary form of Osteosarcoma arise?
de novo
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How does the secondary form of Osteosarcoma arise?
As a complication of another condition such as Paget's disease or radiation
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How does osteosarcoma manifest itsel?
painful bone mass or fracture
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What percent of osteosarcoma sufferers have pulmonay metastases?
20%
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What is the longe term survival rate for Osteosarcoma?
60%
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What are common physical traits of Osteosarcoma?
- Lifts peristeum- called Codman triangle
- Lytic and blastic mass that breaks through cortex
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Osteosarcoma is most common in what age group?
20s
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Osteosarcoma is most common in what body locations?
Distal femur and proximal tibia
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What is Chondroma?
Benign tumor or hyaline cartilage
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What is a Benign tumor or hyaline cartilage?
Chondroma
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Osteochondroma is what?
benign cartilage capped outgrowth (exostosis)
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What are the main bones involved in Osteochondroma?
Long bones of extremities
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Chondrosarcoma is what?
Malignant cartilage forming tumors (produce nepplastic cartilage)
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What parts of the skeleton are most commonly involved in Chondrosarcoma?
- Central/Axial skeleton
- Shoulders, pelvis, ribs, etc.
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What is the second most common malignanat tumor of bone?
Chondrosarcoma
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What is the most common malignant tumor of bone?
Osteosarcoma
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What are th physical manifestations of Chondrosarcoma?
- Painful expansilemass
- fracture
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What group is more susceptible to Chondrosarcoma?
- Males: Females = 2:1
- Older than fourty years
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Where do Chondrosarcoma metastisize to?
Lungs and skeleton
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What visually is differnt about bone of Chondrosarcoma?
Nodules of grey-white glistening tissue
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If you see nodules of grey white glistening tissue in bone, what would be suspect?
Chondrosarcoma
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What is Giant Cell Tumor?
Benign but locally aggressive tumor of proliferating osteoclasts
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What is the term for a benign but locally aggresive tumor of proliferating osteoclasts?
Giant cell tumor
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What type of cell is most significant in Giant cell tumors?
large numebr of osteoclast giant cells
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What proportion of all benign bone tumors are giant cell tumors?
20%
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What age group is affected by giant cell tumors?
20-40 years
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What areas are Giant cell tumors found?
- knee
- distal femur
- proximal tibia
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What are signs of giant cell tumor?
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What is the treatment for giant cell tumors?
cutterage
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What often happens after treatment of Giant cell tumors by cutterage?
Reoccurance
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What is Ewing sarcoma?
Highly malignant small round blue cell tumor
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What disease is of a small round blue cell tumor that is very malignant?
Ewing Sarcoma
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What sex more commonly gets Ewing Sarcoma?
Males
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When in life does Ewing sarcoma occur?
10-15 years, peaks in 20s
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What is the second most common bone tumor in children?
Ewing sarcoma
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What is the orgin of Ewing sarcoma?
neural orgin, exhibits neural pheotype on histology
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WHat is the chromosomal location fo Ewing Sarcoma?
t11:22 transolaction
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What are the symptoms of Ewing sarcoma?
Painful mass and fever
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What is the survival rate for ewing sarcoma?
75% in 5 years
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What bones are commonly affected in Ewing Sarcoma?
long tubular bones and flat bones of the pelvis
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MIC2 indicates what?
It is a marker for neural orgin
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