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What are the lesions associated with Hypothyroidsim?
- Destruction
- atrophy
- fibrosis
- lymphocystic infiltration
- connective tissue changes
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What is the treatment for Hypothyroidism?
Thyroid hormone replacement
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What is mydexema?
Swelling of skin and tissues due to accumulation of mucopolysaccharides
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What is Cretinism?
Hypothyroidism in infancy
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What is the term for hypothyroidism in infancy?
Cretinism
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What are the manifestations of Cretinism?
- Distended abdomen
- Protruded tongue
- Excessive sleeping
- lethargic
- Dwarfism
- mental retardation
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An infant that is suffering from dwarfism, mental retardation, distended abdomne, protruded tongue, lethargy and extensive sleeping likely has what disease?
Cretinism
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What is another name for Hashimoto's thyroiditis?
Struma lymphomatosa
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What is Struma lymphomatosa also called?
Hashimoto's Disease
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What type of disorder is Hashimoto's?
- AutEnlarged thyrois
- muscle weakness
- Increased T4, T3 and I131 uptakes
- Decreased TSH
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A patient that has lost weight has a tremor, emotional instability, muscle weakness, nervousness, rapid HB, enlarged thyroid, Increased T3 and T4 and increasde I131 uptake and decreased TSH likely has:
Hyperthyroidism
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Grave's disease is caused by what?
- Antibody against TSH receptor
- Antibody mimics the TSH effect
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If a person has an antibody against aTSH receptor that is mimicing TSH stimulation, what disease do they have?
Grave's Disease
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What is a physical manifestation of Grave's disease?
- Diffuse enlargement of the thyroid gland - Diffuse toxic goiter
- infiltrative dermopathy and opthalmopathy
- Exophthalmos
- Pretinial myxedema
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What disease characteristically has a diffuse toxic goiter?
Grave's disease
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What disease has infiltrative dermopathy and ophthalmopathy?
- Grave's disease
- oimmune disorder
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What happens to the thyroid gland in Hashimoto's thyroiditis?
Diffuse enlargement
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If the thyroid gland show lymphocystic aggregates and well formed germinal centers and follciles are lines by Hurthle cells, what disease is indicated?
Hashimoto's thyroiditis
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What are the histological changes associated with Hashimoto's thyroiditis?
- Lymphocytic aggregates with well formed germinal centers
- Follicles lined with Herthle cells
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Reidel's thyroiditis is how prominant?
Rare, mostly femal disease
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Describe teh gross morphology of Reidel's thyroiditis:
Stony hard gland adherent to naighboring tissues
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When a stony hard thyroid gland that is adherent to neighboring tissues is found, what disease is indicated?
Reidel's thyroiditis
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What is the pathogenicity of Reidel's thyroiditis?
Fibrous hyalinized tissue takes over thyroid gland, clinically mimicing carcinoma
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When fibrous, hyalinized tissue takes over the thyroid gland, what disease is indicated?
Reidel's thyroiditis
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Reidel's thyroiditis clinically mimics what other disease?
Carcinoma
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How common is Subacute Granulomatous Thyroiditis?
Less common than Hashimoto's disease
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What age group is most susceptible to Subacute Granulaomatous thyroiditis?
30-50 year olds
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What are the manifestations of subacute granulomatous thyroiditis?
- Thyroid pain, enlargement and fever
- Hyperthyroidism followed by Hypothyroidism
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A person presenting with Hyperthyroidism and then hypothyroidism, painand enlargement in the thyroid and fever, likely has what disease?
Subacute Granulomatous Thyroiditis
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Describe the early of three stages of Subacute Granulomatous thyroiditis:
- disruption of follicles
- PMN response
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Describe the later of three stages of Subacute Granulomatous thyroiditis:
plump macrophages around damaged follicles or colloid pools
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Describe the Late of three stages of Subacute Granulomatous thyroiditis:
Chronic inflammation and fibrosis
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What stage of Subacute Granulomatous thyroiditis includes chronic inflammtion nd fibrosis of the thyroid?
Late stage (stage 3 of 3)
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What stage of Subacute Granulomatous thyroiditis includes plump macrophages around damaged follicles and colloid pools?
Later stage ( middle of 3)
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What stage of Subacute Granulomatous thyroiditis includes disruption of the follicles and PMN response
Early stage (1 of 3)
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Hyperthyroidism is caused by what?
- Grave's disease
- Toxic nodular goiter
- thyroid neoplasm
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Grave's disease
Toxic nodular goiter
thyroid neoplasm can all cause what disease?
Hyperthyroidism
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What lesions are associated with hyperthyroidism?
- Diffuse hyperplasia
- Lymphocytic infiltration
- Hyperplastic nodule
- Secretory neoplasm
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What disease is indicated by Diffuse hyperplasia, lymphocytic infiltration, hyperplastic nodule and Secretary neoplasm?
Hyperthyroidism
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How does hyperthyroidism manifest itself?
- Tremor
- Nervousness
- Emotional instability
- heat tolerance
- Rapid HB
- weight loss
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