An Adrenal tumor, tumor in the lungs, tumor in the anterior pituitary or steroid treatmens may cause what disease?
Cushing's syndrome
What is the direct cause of cushing's syndrome?
Increased ACTH
What does the excessive ACTH production cause in Cushing's syndrome?
Excess corticosteroids
How does Cuching's syndrome manifest itself?
Obeisity'Easily Bruised
Purple striae
Hypertension
Osteoporosis
Pathological fracture
Hirsutism
Psychosis
muscle weakness
hyperglycemia
What cause's Conn's syndrome?
Aldosterone secreting adrenal adenoma
An Aldosterone secreting adrenal adenoma causes what disease?
Conn's syndrome
What is the pathological effect of Conn's syndrome?
Excretion of potassium
Retension of Sodium
What adrenal disease causes the excretion fo K and the retension fo Na?
Conn's syndrome
What is the treatment for Conn's syndrome?
removal of adenoma
How does Conn's syndrome manifest itself?
Muscle weakness
Hypertension
Low serum K
high serum Na
What disease is suspect if a person has high serum Na and low serum K, hypertension adn muscle weakness?
Conn's syndrome
Pheochromocytoma are derived from what type of cell?
Cromaffin cells
What disease is derived from cromaffin cells?
Pheochromocytoma
Is Pheochromocytoma benign or malignant?
Usually benign, 10% malignant
What does pheochromocytoma cause?
increased levels of catecholamines and their metabolic breakdowns
What is the treatment for pheochromocytoma?
surgical resection
What is an uncommon but important cause of surgically correctable hypertension?
Pheochromocytoma
A Neuroblastoma of the adrenal medulla is usually found in people of what age?
children under 5
How is neuroblastoma treated?
surgical resection
Is Neuroblastoma malignant?
Very malignant
What does a neuroblastoma do?
produces catecholamines
What is MEN?
multiple endocrine neoplasia
What causes multiple endocrine neoplasia?
autosomal dominant genetic condition that preisposes to hyperplasia of many endocrine organs
What disease is autosomal dominant and predisposes to hyperplasia of endocrine organs?
Multiple Endocrine Neoplasia
What is the name for MEN type I?
Werner's syndrome
What type of inheritance does Werner's syndrome have?
Autosomal dominant
Where is the gene for Werner's syndrome located?
11q13
What does Werner's syndrome cause in what organs?
Parathyroid: Hyperparathyroidism
Pituitary: Prolactin secreting tumor
Pancreas: gastrin secreting tumor which lead to peptic ulcers
What disease causes:
–Parathyroid: Hyperparathyroidism
–Pituitary: prolactin secreting tumor
–Pancreas: gastrin secreting tumor which can lead to peptic ulcers.
Werner's syndrome
What disease is MEN IIa?
Sipple syndrome
What is Sipple syndrome?
medullary thyroid carcinoma
pheochromocytoma
parathyroid hyperplasia/adenoma
What disease causes Medullary carcinoma, pheochromocytoma and parathyroid hyperplasia/adenoma?
MEN IIa: supple syndrome
What chromosome is Supple syndrome MENIIa on?
10
MEN IIb or William syndrome is the same as MEN IIa except:
multiple mucocutaneous neuromas
no parathyroid symptoms
What disease causes mucucutansious neuromas, pheochromochytoma and medullary thyroid carcinoma?
MEN IIb or William Syndrome
Almost all endocrine disprders resulting in excessive production of a hormone are from what?