PTG 105 -Exam 3- Lecture 16-3

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  1. Toxins that are not filtered or excreted properly due to viral hepatitis often settle in the skin causeing what?
  2. What type of virus is hepatitis A?
    RNA virus
  3. Which strain of Hepatitis is the most benign?
    Hep A
  4. How does Hep A spread?
    Fecal contamination of water and food
  5. What is the incubation period for Hep A?
    2-6 weeks
  6. The symptoms of Hep A are insiduous (T/F)?
    False, they are abrupt
  7. Which type of Hepatitis has no carrier state, no chronic hepatitis, rarely leads to liver failure and is rarely fatal?
    Hep A
  8. Hep A has a high incidence in the United States?
    False, very low
  9. Why has Hep A declined 92% since 1995 in the US?
    Introduction of the Hep A vaccine
  10. The incidence of Hep A in the US can be described as:
    Declining due to the introduction of a vaccine in 1995
  11. What countries have very low Hep A?
    US, Canada and Australia
  12. How many doses are in the Hep A series?
  13. How many single anitgen hep A vaccines exist?
  14. HAVRIX contains what?
    inactivated Hep A virus
  15. HAVRIX protects against what?
    HEP A
  16. How do you diagnose actuet Hep A illness?
    elevated IgM anti-hepatitis A antibodies in teh serum
  17. How do you detect A past infection with Hep A?
    elevated IgG anti-hepatitis A anitbodies in the serum (no IgM)
  18. What period do Hep A viruses shed into teh fecal matter?
    2 weeks before to 1 week after illness onset
  19. Where do Hep A viruses shed from?
  20. Hep B is what type of virus?
    DNA virus
  21. Hep B is a completley benign disease (T/F)?
    False, it is potentially serious
  22. What is the incubation period for Hep B?
    1-6 months
  23. What type of onset is experienced with Hep B?
  24. How is Hep B diagnosed?
    detection in serum of antigens and antibodies (more comlex than hep A)
  25. Describe the morphology of the Hep B virus?
    • From out to in:
    • HBs surface porteins
    • Protein coat
    • Core protein HBc
    • DNA
    • DNA polymerase
  26. What are the routes of transmission for Hep B?
    • Parenteral blood and body fluids
    • Sexual intercourse
    • Vertical (mom to babe)
  27. Where is teh incidence of Hep B very high (>8%)?
    Africa and southeast Asia
  28. What are the Hep B risk factors?
    • Sex w/o long term monogamous relationship
    • Men with men
    • IV drug users
    • Live with HBV infected indivual
    • Health care and public saftey workers
    • hemodialysis patients
    • Travelers to Afric and Asia
  29. Sex w/o monagamy, sex between men, IV drug use, living with an infected person, Healthcare or Public saftey workers, Hemodialysis patients and travelers all have an increaed risk of what Hep strain?
  30. During Hep B illness what levels of serum are highest?
    • first: HBs antigen
    • then: HBe antigen
    • third: Anti-HBc
  31. What serum level remains high throughout Hep B infection?
  32. What serum level goes down after the illness from Hep B?
    IgM Anit-HBc
  33. What appears in the serum before the onset of symptoms in Hep B?
    HBs Antigen
  34. How long do HBs antigens remain high in the serum?
    3-6 months
  35. Presence of HBs or more than 6 months indicates what?
    Carrier state
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PTG 105 -Exam 3- Lecture 16-3
PTG 105 -Exam 3- Lecture 16-3
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