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Carrier state of Hep B is indicated by what?
Presence of HBs antigens for over 6 months
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Anti HBs confers what?
lifelong immunity
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Lifelong immunity for HBs can be conferd by what?
Anti-HBs
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What serum levels indicate active viral replication in Hep B?
HBe antigen and HBV DNA
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HBe antigens and HBV DNA indicate what in a person with Hep B?
Active disease state, repliating virus
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What percent of Hep B sufferers have complete recovery and subclinical disease?
60%
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What percent of Hep B sufferers have acute hepatitis, but completely recover?
25%
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What percent of Hep B cases end with the person as a healthy carrier?
10%
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What percent of Hep B infected individuals have a persistent infection?
5%
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Of those Hep B sufferers that have a persistant infection, what percent recover eventually?
90%
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Of those Hep B sufferers with a persistant infection, what percent develop chronic hepatitis?
10%
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Of the 10% of Hep B sufferers with a chronic infection, 10% develop hepatitis , what percent of those with hepatitis develop cirrhosis?
20-50%
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Massive or fulmitant hepatic failure is a common outcome of Hep B?
False, it is uncommon
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How is an acute infection of Hep B treated?
no treatment availbale, just supportive
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What type of Hep B infection has no treatment available (only supportive)?
Acute infection
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What treatments are availbale for chronic Hep B infection?
inerferon alpha-2a and anti-virals
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What type of Hep B infection can be treated with antivirals and interferon alpha-2a?
Chronic hep b infection
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Hep C is what type of virus?
DNA virus
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What is the incubation period of Hep C?
2 weeks to 6 months
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How does Hep C spread?
Similar to Hep B (blood, fluids, etc.)
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What strain of Hep B causes the most cases of post-transfusion hepatitis?
Hep C
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Hep B or Hep C is more likley to develop into chronicity, Cirhosis and carcinoma?
Hep C
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The symptoms of Hep C are similar to what other Hepatitis strain?
Hep B
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What two main viral strains of hepatitis are most likley to lead to hepatocellular carcinoma?
B and C
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What is the chance of aquiring Hep C from a blood transfusion (currently with advanced screen methods)?
1 in 2 million units
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Before 1992 what was the leading method for aquiring Hep C?
blood transfusion
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How do you screen for Hep C?
- look for anti-HCV by:
- EIA or RIBA
- Tests to detect presence of virus:
- HCV RNA via PCR
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What is RIBA?
recombinant immunoblot assay
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What Hepatits strain would you test for using EIA, RIBA or PCR?
Hep C
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What is the treatment for chronic Hep C?
pegylated interferon and ribavirin
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What Hep strain/type would you treat with pegylated interferon and ribavirin?
Hep C
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What are the characteristics of Hep Delta virus?
- Requires Hep B for replication
- Infection only in those with HBV
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Which Hepatitis strain requires a current infection of Hep B?
Hep Delta
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HEV is similar to what other hep strain?
Hep A
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Describe the characteristics of Hep E?
- acute
- self-limiting
- no chronicity or carrier state
- can cause fulmitant hep in preganant women
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What Hep strain can cause fulmitant hep in pregnant women?
Hep E
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