-
anterior lobe of the piruitary
adenohypophysis
-
posterior lobe of pituitary
neurohypophysis
-
hypothalamus communication with the anterior pituitary
releasing regulating factors delivered through portal blood vessels
-
hypothalamus communication with posterior pituitary
neuronally
-
inhibitory factors released in hypothalamus
-
moa of the release of regulation factors
G protein-GTP complexes activate adenylyl cyclase producing the second messenger cAMP
-
G protein for GnRH & TRH
G14
-
G protein for GHRH,CRH,ACTH,FSH,LH
Gs
-
two inhibitory mechanisms of DA
- reduces adenylyl cyclase activity
- inhibits prolactin secretion
-
inhibitory mechanism of SST
- exerts effects on potassium channel
- inhibits GH secretion
-
polypeptide
secreted by somatotrophs
moa - activates JAK-STAT pathway
ind - dwarfism
growth hormone
-
2 growth hormone recombinant products
- somatropin - humantrope
- somatrem - protropin
-
3 AE of growth hormone recombinant products
- hyperglycemia
- hypothyroidism
- antibodies to GH
-
drug interactions with GH recombinant products
glucocorticoids
-
synthetic IGF analog
- rinfabate - increlex
- mecasermin rinfabate - iplex
-
synthetic GHRH
ind - diagnose pituitary GH secretory capacity in children
Sub Q
sermorelin - geref
-
4 growth hormone antagonists
- somatostatin
- ocreotide - sandostatin
- lanreotide - somatuline
- pegvisomant - somavert
-
gonadotropins effects on women
- ovarian follicle development (FSH)
- ovarian steroidogenesis (FSH,LH)
-
gonatotropin effects on men
- regulation of spermatogenesis (FSH)
- stimulus for testicular androgen production (LH)
-
2 FSH analogs
- urofollitropin - uFSH
- follitropin alfa and beta
-
FSH & LH analog
menotropin - pergonal
-
3 LH analogs
- human chorionic gonadotropin (hCG)
- chorigonadotropin alfa (rhCG)
- luteinizing hormone - lutropin alpha
-
difference between pulsatile and non release of GnRH
- pulsatile - stimulates release of LH & FSH
- non - inhibits release of LH & FSH, causing hypogonadism
-
GnRH analog
gonadorelin - factrel
-
4 formulations of GnRH analogs
- gonadorelin - lyophilized powder for IC & SC
- leuprolide - solution SC, micrispheres IM
- nafarelin - nasal spray
- goserelin - implantable cylinders, SC, inj
-
2 GnRH antagonist
- ganirelix - antagon
- cetrorelix acetate - cetrotide
-
2 main functions of oxytocin
- promotes uterine contraction during labor
- stimulates milk ejection
-
3 uses for desmopressin acetate
- hypothalamic diabetes insipidus
- nocturnal enuresis
- coagulopathy
-
2 vasopressin antagonist
- conivaptan - vaprisol
- tolvaptan - samsca
-
2 uses of vasopressin antagonists
euvolemic and hypervolemic hyponatremia
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