-
beyond use date for non-aqueous liquids and solid formulations
no later than 25% of the time remaining till products expiration
OR
6 months (whichever comes first)
-
Beyond use date for water containing oral preparations
no later than 14 days (stored at cold temps)
-
beyond use date for topical/dermal/mucosal formulations
no later than intended duration of therapy
OR
30 days (whichever comes first)
-
Class A/Class III balances are used for what weights?
loads of 120 mg - 120 g
-
Class B balances are used for what weights?
648 mg
-
what is the minimum weighable quantity (LWQ) for Class A balances?
120 mg
-
an electronic balance can weigh between what range?
0.001 mg to 5 kg
-
medications and ingredients that have been incorporated into sticks include:
- local anesthetics
- sunscreens
- oncology drugs
- antivirals
- antibiotics
-
what are cold sores/fever blisters caused by?
herpes simplex virus type 1 (HSV-1)
-
what does HSV do?
- invades cells in the epidermis (outer layer of skin)
- causes fluid-filled blisters around mouth or on lips
-
relationship between HSV and age?
infection increases with age
-
MOA of trigger factors for HSV
unknown
-
types of lip balm bases
- melting bases (for soft sticks)
- moistening bases (for hard sticks)
-
melting bases for lip balm - what do they do and what types are there?
soften at body temp and spread drug/vehicle over the lip
-
soft opaque bases for lip balm
- type of melting base for soft sticks
- waxes, oils, petrolatum, cocoa butter, PEG
-
soft clear bases for lip balm
- type of melting base for soft sticks
- sodium stearate/glycerine mixes, propylene glycol
-
moistening bases for lip balm
- bases for hard sticks
- crystalline powder fused by heat and held together by binder
- needs moistening for activation
-
polyethylene glycol description
non-toxic odorless, neutral, luricating, nonvolatile, and nonirritating
-
what is polyehtylene glycol used as?
- solvent
- dispensing agent
- ointment
- suppository bases
- vehicle
- tablet excipient
-
what does PEG in combo with a number mean?
average molecular weights
-
PEG's solubility?
- water soluble
- soluble in many organic solvents including aromatic hydrocarbons, but not aliphatics
-
-
shelf life of lip balm?
6 months
-
store lip balm at what temp?
5-25'
-
What is a troche?
- a compressed lozenge
- designed to dissolve or disentegrate slowly in the mouth
-
the choice of a troche is limited by what?
- flavor, dose, chemical incompatability
- i.e. benzocaine is incompatible with the candy base
-
the base of a hard lozenge vs. a soft lozenge
- hard: solid syrup of sugar with adhesive
- soft: PEG base with soft texture (usually transparent)
-
Drug release of hard vs. soft lozenge
- hard: slow, uniform dissolution w/o disintegration
- soft: can be chewed or dissolved in mouth
-
the effect of hard vs. soft lozenges
- hard: local demulcent effect as some excipient are released slowly; spreads uniformly over mucosal surface
- soft: chewable lozenge has a glycerinated gelatin base (delivers drug to the GIT)
-
temperature requirements of hard vs soft lozenge
- hard: needs high temps - not good for thermolabile drug
- soft: doesn't need high temps
-
xerostomia; what is it and what causes it
- dry mouth
- aging, systemic disease, radiation therapy or medication
-
how to calibrate a troche mold
- 1. make sure mold is clean and dry
- 2. melt enough base to fill the cavities
- 3. pour into the mold, cool and dry
- 4. remove lozenges and weigh, dividing the total weight by the number of lozenges
- 5. gives the average weight of lozenge for that base in the mold
-
special consideration of troches with a PEG base
hygroscopic - might soften when exposed to inc temps
-
stability of a troche
6 months
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