1. What are obligate intracellular parasites unable to self-replicate?
  2. What is the term for the entire viral particle?
  3. What is the term for the protein coat that encloses the genetic material?
  4. What is the term for the protein subunit that makes up the capsid?
  5. What is the term for what is composed of the capsid and the genetic material?
  6. What is the outer coating that is composed of a phospholipid bilayer?
  7. What is the term for viruses with NO envelope?
    Naked nucleocapsids
  8. What is the term for the attachment of the virus to a specific receptor on the host cell?
  9. What is the term for what occurs when there is either the separation of the capside from the genome or rearrangement of the capsid proteins exposing the genome for transcription and replication?
  10. What is the term for the stage when the genetic material is replicated but intact virions are not yet detectable?
    Eclipse period
  11. What does Viral Transport Medium contain?
    • Buffered saline
    • Protein stabilizers
    • Antimicrobials that inhibit bacterial and fungal growth
  12. Name common upper respiratory infections
    • Rhinovirus
    • Influenza
    • Parainfluenza
    • RSV
    • EBV
    • Coronavirus
  13. Name common croup and bronchitis viral infections
    • Influenza
    • Parainfluenza
    • RSV
    • Adenovirus
  14. What viruses can cause pneumonia in children?
    • RSV
    • Parainfluenza
    • Adenovirus
    • VZV (varicella-zoster virus)
  15. What viruses can cause pneumonia in adults?
    • Influenza
    • VZV (varicella zoster virus)
    • CMV
    • RSV
  16. Name the viruses that cause viral meningitis
    • Enterovirus
    • Echovirus
    • HSV-1
    • HSV-2
    • VZV (varicella zoster virus)
  17. What viruses cause encephalitis?
    • HSV
    • VZV
    • Arboviruses
  18. What viruses causes Cutaneous infections?
    • HSV-1
    • HSV-2
    • VZV
    • Echovirus
    • Measles
    • Rubella
    • Enterovirus
    • Molluscum Contagiosum
    • Parvovirus B-19
  19. What viruses cause Genital infections?
    • HSV-2
    • Human papillomavirus
  20. What viruses cause gastroenteritis?
    • Rotavirus
    • Norwalk viruses
    • Adenoviruses
    • Calciviruses
  21. What viruses cause eye infections?
    • HSV
    • Adenovirus
    • VZV
  22. What viruses cause neonatal infections?
    • HSV
    • CMV
    • Rubella
  23. What do DNA viruses produce, that show in the cell?
    Nuclear inclusions
  24. What do RNA viruses produce that show up in the cell?
    Cytoplasmic inclusions
  25. What inclusion does CMV produce?
    Basophilic intranuclear inclusions referred to as "owl eye" inclusion
  26. What virus produces the clinical manifestations of:
    Gingivostomatitis in children and young adults
    Recurrent oral-labial infection (cold sores)
    Infection of the cornea (keratitis)
    Herpes encephalitis
  27. What virus produces the clinical manifestations of:
    Genital herpes
    Neonatal herpes
  28. What virus produces the clinical manifestations of:
    Chickenpox (primary infection
    Singles or Zoster (reactivation)
    VZV (varicella zoster)
  29. What virus produces the clinical manifestations of:
    Asymptomatic infection
    Heterophile-negative mononucleosis
    Fever hepatitis syndrome in neonates and transplant patients
    Interstitial pneumonia in immunocompromised patients
    Cytomegalovirus (CMV)
  30. What virus produces the clinical manifestations of a heterophile-positive mononucleosis?
    Espstein-Barr virus
  31. What clnical conditions does EBV (epstein-barr virus cause)?
    • Infectious mononucleosis
    • Burkitt lymphoma
    • Nasopharyngeal carcinoma
    • Hodgkin disease
    • Other lymphomas
  32. What virus produces the clinical manifestations of Roseola (6th disease)?
    Human herpesvirus 6
  33. What virus produces the clinical manifestation of Roseola and febrile disease in children?
    Human herpesvirus 7
  34. What virus produces the clinical manifestation of Kaposi's sarcoma?
    Human herpesvirus 8
  35. What virus causes smallpox?
    Variola major
  36. What virus causes molluscum contagiosum?
  37. What virus causes zoonosis?
    Monkeypox virus
  38. What type of infection does adenovirus cause?
    • Respiratory tract infections (especially in young children)
    • UTIs
    • GI infections
    • Pharyngitis
    • Eye infections in newborns, immunocompromised patients, and military recruits (b/c of close living conditions)
  39. What are the members of orthomyxoviruses?
    Influenza viruses A, B, and C
  40. What do the orthomyxoviruses have on their surface?
    • Hemagglutinin (HA)
    • Neuraminidase (NA)
    • Both immungens
  41. What occurs when point mutations occur in the viral genes encoding the HA (hemagglutinin) and NA (neuraminidase) spikes?
    Antigentic drift
  42. What occurs following a major change (reassortment) of the RNA genome when a single host cell is infected with 2 different influenza viruses?
    Antigenic shift
  43. What is included in Lentiviruses?
    • HIV-1
    • HIV-2
  44. What members are included in Parmyxoviruses?
    • Parainfluenza
    • Mumps
    • Morbillivirus
    • RSV
  45. What clinical condition is an infection of the parotid glands, causing swelling and difficulty in swallowing?
  46. What virus causes rubeola or measles?
  47. What clinical condition has necrotic vesicles with a whit center surrounded by erythema on the oral mucosa, referred to as Koplik spots?
  48. What clinical condition is characterized by the formation of syncytia - an infected cell can cause fusion with adjacent cells, producing giant multinucleated cells?
  49. What members are included in Picornaviruses?
    • Enteroviruses
    • Poliovirus
    • Coxsackie virus
    • Rhinoviruses
  50. What virus causes hand, foot, and mouth disease of humans?
    Coxsackie A virus
  51. What virus causes about 1/3 of all cases of myocarditis and also associated with meningitis?
    Coxsackie B
  52. What virus is a frequent cause of the common cold?
  53. What virus has a
    Wheel-like (spoke) appearance
    Most important cause of GI infections in children less than 2 yrs of age
  54. What are the members of Caliciviridae?
    • Norovirus - include Norwalk virus
    • Sapovirus
    • Lagovirus
    • Vesivirus
  55. What are the members of Togaviridae?
    • Rubivirus - includes Rubella
    • Alphavirus
  56. What are the members of Flaviviridae?
    West Nile Virus
  57. What virus:
    Had birds as the primary reservoir and mosquitos as the vectors
    Can be mild or asymptomatic infections in healthy individuals or
    Fatal encephalitis
    West Nile Virus
  58. What clinical condition is caused by rhabdovirus?
  59. What virus is diagnostic with Negri bodies (although, not recommended due to low sensitivity)?
  60. Once exposed to rabies, how long can one wait to get treated?
    Maximum of 72 hours because without treatment, infection is 100% fatal
  61. What are the members of Filoviridae?
    • Marburg virus
    • Ebola virus
  62. What viruses:
    Have bats that are thought to be the reservoir
    Infection by these viruses produces hemorrhagic fever with high fatality rates
    Most cases occur in Africa
    • Marburg virus
    • Ebola virus
Card Set
Intro, Viral Agents, DNA and RNA Viruses