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PTG 105- Exam 3- Lecture 17-3
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How common are Sex cord stromal tumors?
Uncommon
What is a marker for yolk sac tumors?
Alpha feto protein (AFP)
Alpha feto protein (AFP) is a marker for what tumor?
Yolk sac tumors
AFP stands for:
Alpha feto protein
What is a marker for Choriocarcinoma?
Human Chorionic Gonadotrphin (HCG)
Human Chorionic Gonadotrophin is a marker for what disease?
Choriocarcinoma
What is the age range for peak incidence of Germ cell tumors?
15-35 years
What are the risk factors for Germ cell tumors?
Cryptochidism
Kleinfelter’s syndrome
Abnormal chromosome 12
White
Sibling of person with a germ cell tumor
What is another name for testicular dysgenesis?
Kleinfelter’s disease
Kleinfelter’s disease is also called:
Testicular dysgenesis
How much more likely are white males to develop a germ cell tumor than black males?
5 times
How much more likely are siblings of a person with a GCT to develop a GCT?
10 times
What do germ cell tumors often secrete?
Tumor markers
Why are tumor markers important?
Aid in diagnosis
Aid in treatment followup
What arises from a precancerous lesion or more specifically an intratubular germ cell neoplasia?
Germ cell tumor
Where do germ cell tumors arise from (anatomically)
Seminiferous tubule
What two types of Germ cell tumors exist?
Seminoma and Non-seminomatous tumor
What two general characteristics differentiate Seminomas from Non-seminomatous tumors?
Behavior and response to treatment
Which type of germ cell tumor has a better prognosis?
Seminoma
How are Seminomas spread?
Through the lymphatic system to the lymphs
What characteristics does a seminoma have?
Spreads to lymph node through lymph system
Confined to the testes
Good prognosis
What characteristics do Non-seminomatous tumors have?
Spread earlier than seminos
Spread via the blood to liver and lungs
What are four examples of non-seminomatous tumors?
Choriocarcinoma
Yolk Sac cancer
Teratoma
Embryonal cancer
Which type of germ cell tumor is the type that causes Yolk sac tumors, Choriocarcinoma, Teratoma and Embryonal carcinoma?
Non-seminomatous tumor
Which type of GCT spread via the blood to the lungs and liver?
Non-seminomatous tumors
Which type of Germ cell tumor is mostly confined to the testes but can travel through the lymph to the lymph nodes?
Seminoma
Which type of GCT spreads the earliest?
Non-seminomatous tumor
What is the most common GCT?
Seminoma
Which type of GCT is composed of uniform tumor cells arranged in a nest?
Seminoma
Which type of GCT has fibrous septa that contain lymphocytes?
Seminoma
If you saw uniform tumor cells arranged in a nest and fibrous septa that contain lymphocytes histologically, what would your diagnosis be?
Seminoma
What is the tumor marker for Seminomas?
Secrete placental alkaline phosphate (SLAP)
Secrete placental alkaline phosphate is what?
Tumor marker for Seminomas
At what stage do patients present with Seminoma?
Early stages
What is the cure rate for stage 1 or 2 seminoma?
95%
Is Seminoma sensitive to chemotherapy and radiation?
Yes extremely sensitive
What GCT tumor is very sensitive to radiation and chemotherapy?
Seminoma
What is the most common primary testicular tumor in children?
Yolk Sac tumor
What age range is most susceptible to Yolk Sac tumor?
< 3 years
What tumor marker s secreted by Yolk Sac tumor?
Alpha feto Protein (AFP)
What is pathologically distinctive about a Yolk sac tumor?
Distinctive Schiller Ducall bodies
What disease do distinctive Schiller Duvall bodies indicate?
Yolk Sac tumor
What is a Schiller Duvall body?
Need to determine
What type of Non-seminomatous tumor is considered aggressive?
Choriocarcinoma
Choriocarcinoma would be classified as non-aggressive (T/F)?
True
False
False, it is very aggressive
Where does Choriocarcinoma usually spread to?
Lungs
Liver
Brain
Mediastinum
Author
kyleannkelsey
ID
212089
Card Set
PTG 105- Exam 3- Lecture 17-3
Description
PTG 105- Exam 3- Lecture 17-3
Updated
2013-04-08T04:26:10Z
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