PTG 105- Exam 3- Lecture 17-3

  1. How common are Sex cord stromal tumors?
  2. What is a marker for yolk sac tumors?
    Alpha feto protein (AFP)
  3. Alpha feto protein (AFP) is a marker for what tumor?
    Yolk sac tumors
  4. AFP stands for:
    Alpha feto protein
  5. What is a marker for Choriocarcinoma?
    Human Chorionic Gonadotrphin (HCG)
  6. Human Chorionic Gonadotrophin is a marker for what disease?
  7. What is the age range for peak incidence of Germ cell tumors?
    15-35 years
  8. What are the risk factors for Germ cell tumors?
    • Cryptochidism
    • Kleinfelter’s syndrome
    • Abnormal chromosome 12
    • White
    • Sibling of person with a germ cell tumor
  9. What is another name for testicular dysgenesis?
    Kleinfelter’s disease
  10. Kleinfelter’s disease is also called:
    Testicular dysgenesis
  11. How much more likely are white males to develop a germ cell tumor than black males?
    5 times
  12. How much more likely are siblings of a person with a GCT to develop a GCT?
    10 times
  13. What do germ cell tumors often secrete?
    Tumor markers
  14. Why are tumor markers important?
    • Aid in diagnosis
    • Aid in treatment followup
    • What arises from a precancerous lesion or more specifically an intratubular germ cell neoplasia?
    • Germ cell tumor
  15. Where do germ cell tumors arise from (anatomically)
    Seminiferous tubule
  16. What two types of Germ cell tumors exist?
    Seminoma and Non-seminomatous tumor
  17. What two general characteristics differentiate Seminomas from Non-seminomatous tumors?
    Behavior and response to treatment
  18. Which type of germ cell tumor has a better prognosis?
  19. How are Seminomas spread?
    Through the lymphatic system to the lymphs
  20. What characteristics does a seminoma have?
    • Spreads to lymph node through lymph system
    • Confined to the testes
    • Good prognosis
  21. What characteristics do Non-seminomatous tumors have?
    • Spread earlier than seminos
    • Spread via the blood to liver and lungs
  22. What are four examples of non-seminomatous tumors?
    • Choriocarcinoma
    • Yolk Sac cancer
    • Teratoma
    • Embryonal cancer
  23. Which type of germ cell tumor is the type that causes Yolk sac tumors, Choriocarcinoma, Teratoma and Embryonal carcinoma?
    Non-seminomatous tumor
  24. Which type of GCT spread via the blood to the lungs and liver?
    Non-seminomatous tumors
  25. Which type of Germ cell tumor is mostly confined to the testes but can travel through the lymph to the lymph nodes?
  26. Which type of GCT spreads the earliest?
    Non-seminomatous tumor
  27. What is the most common GCT?
  28. Which type of GCT is composed of uniform tumor cells arranged in a nest?
  29. Which type of GCT has fibrous septa that contain lymphocytes?
  30. If you saw uniform tumor cells arranged in a nest and fibrous septa that contain lymphocytes histologically, what would your diagnosis be?
  31. What is the tumor marker for Seminomas?
    Secrete placental alkaline phosphate (SLAP)
  32. Secrete placental alkaline phosphate is what?
    Tumor marker for Seminomas
  33. At what stage do patients present with Seminoma?
    Early stages
  34. What is the cure rate for stage 1 or 2 seminoma?
  35. Is Seminoma sensitive to chemotherapy and radiation?
    Yes extremely sensitive
  36. What GCT tumor is very sensitive to radiation and chemotherapy?
  37. What is the most common primary testicular tumor in children?
    Yolk Sac tumor
  38. What age range is most susceptible to Yolk Sac tumor?
    < 3 years
  39. What tumor marker s secreted by Yolk Sac tumor?
    Alpha feto Protein (AFP)
  40. What is pathologically distinctive about a Yolk sac tumor?
    Distinctive Schiller Ducall bodies
  41. What disease do distinctive Schiller Duvall bodies indicate?
    Yolk Sac tumor
  42. What is a Schiller Duvall body?
    Need to determine
  43. What type of Non-seminomatous tumor is considered aggressive?
  44. Choriocarcinoma would be classified as non-aggressive (T/F)?
    False, it is very aggressive
  45. Where does Choriocarcinoma usually spread to?
    • Lungs
    • Liver
    • Brain
    • Mediastinum
Card Set
PTG 105- Exam 3- Lecture 17-3
PTG 105- Exam 3- Lecture 17-3