PTG 105 - Exam 3 - LEcture 15 - 7

  1. What are common causes of defective digestion?
    • Pancreatic insufficiency
    • Surgical removal of portions of the bowel
  2. Pancreatic insufficiency and removal of bowel segments can cause what issue?
    Defective digestion
  3. What are the symptoms of Malabsorption?
    • Steatorrhea
    • Weight loss
    • Vit. Mineral deficiencies
    • Abnormal Fat and Carb tests
    • Abnormal intestinal biopsy ( celiac disease)
  4. What is Steatorrhea?
    Large bulky fatty stools
  5. What is the name for large bulky fatty stools?
  6. What minerals and Vitamins are commonly deficient in a person with malabsorption?
    Ca, Fe, B12 and FA
  7. A person presenting with an deficiency in Vit. B12, Fe, FA and Ca could likely have what general disease?
  8. What is the prevalence of Celiac disease in the USA?
  9. What is the most common cause of severe malabsorption?
    Celiac disease
  10. What is another name for Celiac disease?
    Celiac Sprue
  11. Where is gluten found?
    Wheat and Oats
  12. In what organ does Celiac disease manifest?
    Small intestine (mucosa)
  13. What part of the small intestine is affected by Celiac disease?
    Mucosa, small intestinal epithelium
  14. Describe the pathogenesis of Celiac disease:
    Gluten causes immune injury to the small intestinal mucosa, causing loss of villi and absorptive surface
  15. What antibody levels are elevated in a person with celiac disease?
    • Anti-transglutaminase
    • Antiendomysial
    • Antireticulin
    • Antigliadin
  16. What do people with celiac disease have a great risk of developing?
    • Small intestine lymphomas
    • GI carcinoma
    • Breast carcinoma
  17. What disease creates a greater risk of small intestine lymphomas and GI and Breast carcinomas?
    Celiac Disease
  18. Diagnosis of Celiac disease on a biopsy would reveal what mucosal morphology?
    • Atrophied villi
    • Flat small intestinal mucosa
  19. A biopsy from the small intestine that revealed small flat intestinal mucosa and atrophy of villi would indicate what disease?
  20. What is the cause of acute appendicitis?
    Usually unknown, sometimes fecalith in appendix
  21. What are the symptoms and signs of acute appendicitis?
    • Abdominal pain
    • Rebound tenderness
    • Fever
    • Leukocytosis
  22. What disease presents as Leukocytosis, abdominal pain, rebound tenderness and fever?
    Acute appendicitis
  23. What are potential complications of acute appendicitis?
    • Perforation leading to peritonitis
    • Abscess
  24. Abscess and perforation leading to peritonitis are complication of what disease?
    Acute appendicitis
  25. Describe the pathology of acute appendicitis:
    Inflammation of the appendix
  26. Inflammation of the appendix is termed:
    Acute appendicitis
  27. What are the two diseases that cause of inflammatory bowel disease?
    • Ulcerative colitis
    • Crohn’s disease
  28. Crohn’s disease and Ulcerative colitis are both what type of larger disease grouping?
    Inflammatory bowel disease
  29. What is the cause of inflammatory bowel disease?
    Not yet known
  30. Describe inflammatory bowel disease?
    Inflammation destroys the mucosa and causes malabsorption
  31. What group has the highest rate of Inflammatory bowel disease?
    Young adults
  32. What are the symptoms of inflammatory bowel disease?
    • Diarrhea
    • Abdominal pain
    • Bleeding
  33. What disease is marked by exacerbation adnd remission?
    Inflammatory bowel disease
  34. What are the two complication of Inflammatory Bowel disease discussed in class?
    • Cancer (late, usually after 10 years)
    • Polyarthritis
  35. Polyarthritis and Cancer are complications of what disease?
    Ulcerative colitis, Crohn’s disease or inflammatory bowel disease
  36. Ulecrative colitis and Crohn’s disease only cause complications in the bowel (T/F)?
    False, they both have extra-intestinal manifestations like polyarthritis
  37. List six potential causes for Ulcerative colitis:
    • Stress
    • Diet
    • Genetic predisposition
    • Drugs
    • Allergens
    • Infections
  38. What inflammatory bowel disease likely has a multi-factoral cause?
    Ulcerative Coliits
  39. The risk for developing cancer is higher with Crohn’s disease or Ulcerative Colitis?
    Ulcerative Colitis
  40. What is the common age range for ulcerative colitis?
  41. What is the common age range of Crohn’s disease?
    10-40 years
  42. Which disease Crohn’s or Ulcerative colitis can involve the alimentary tract?
  43. Which disease, Crohn’s or Ulcerative colitis can involve the colon?
    Ulcerative colitis
  44. Which disease, Crohn’s or Ulcerative, creates diffuse continuous inflammation?
    Ulcerative colitis
  45. Which disease, Crohn’s or Ulcerative, creates patchy inflammation?
  46. Which disease, Crohn’s or Ulcerative, creates mucosal inflammation
    Ulcerative colitis
  47. Which disease, Crohn’s or Ulcerative, caused transdermal inflammation and granulomas in 40-50% of patients?
    Crohn’s disease
  48. Which disease, Crohn’s or Ulcerative, has mild fibrosis?
    Ulcerative colitis
  49. Which disease, Crohn’s or Ulcerative, has marked fibrosis ad thickening of the wall with fissures and fistulas?
  50. Which disease responds well to surgery, Crohn’s or Ulcerative?
    Ulcerative colitis
  51. Which disease does not respond to surgery well, Crohn’s or Ulcerative?
    Crohn’s disease
  52. What type of inflammatory bowel disease runs a high risk of colon cancer?
    Ulcerative colitis
  53. What disease is marked by ulcer formation and crypt abscess formation in the colon?
    Ulcerative colitis
Card Set
PTG 105 - Exam 3 - LEcture 15 - 7
PTG 105 - Exam 3 - LEcture 15 - 7