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Which DM drug has increased risk for lactic acidosis if renal impairment is present?
Metformin
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Unless contraindicated, all T2DM should be treated with which DM drug upon diagnosis?
Metformin
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Which drug that produces hypoglycemia should NOT be treated with orange juice?
Alpha-Glucosidase Inhibitors (can use milk, glucose tab)
-
Which pancreatic cells produce glucagon?
Alpha cells
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Which pancreatic cell produces insulin?
Beta cells
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What peptide hormone is co-secreted with insulin from Beta cells in RESPONSE TO FOOD?
Amylin (inhibits glucagon secretion, delays gastric emptying, satiety agent
-
Which insulin should NOT be used in pregnant women?
Lantus
-
Impairment of ischemic preconditioning increasing cardiac mortality is a concern for what DM drug?
Sulfaureas (b/c heart channels)
-
Which medication is a PPAR selective agonist and takes a long time to be effective?
- TZDs (PPAR--> increase GLUT-4 transporter production,)
- -->insulin must be present to be effective
- --> Actos (Pioglitazone) & Avandia
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Which medication and assist 1st phase insulin secretion and supresses glucagon at the same time, targeting post meal rise?
GLP-1
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Which has a Black Box Warning for hypoglycemia unawareness?
Symlin, especially in Type 1
-
Which analog basal insulin is adminestered once daily?
Lantus
-
Which insulin has a rapid onset, 15min?
Any analog insulin (Humalog, Novolog, Apidra)
-
Which insulin is short acting, onset 30-60min. Has to be taken 45min before eating?
Regular
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