med chem III quiz 7 GA - muscle relaxants

2 ultra-short acting barb
caution in extreme asthmaticus
powder only
very potent CV and respiratory depressants

GA
diagnostic agent
anesthetic induction agent
dissociative anesthesia

GA
no analgesic activity
can cause reduction in plasma cortisol levels

GA
induction and maintenance
continuous sedation
profound respiratory depression

GA
reduce incidence of N/V during surgery
butyrophenone
mild alpha-adrenergic blocker
reduce dosage in elderly

GA
very good relief of amnesia
short acting benzo
overdose managed with flumazenil

GA
inhaled
known to oxdize and inactivate B12
commonly used for dental procedures
danger of hypoxia

2 GA
volatile liquids
useful for vaginal and C-section
can cause renal damage

GA
volatile liquid
specialized vaporizer needed
do not use in children

GA
volatile liquid
useful for peds, no resp. irritation

first local anesthetic discovered
tropane alkaloid
ambiphilic

LA
ester
coadminister with antihistamine
topical use only

LA
ester
infiltration and peripheral nerve block

LA
ester
combo with lidocaine cream

LA
amide
CV use management of cardiac arrhythmias
rapid first pass

LA
amide
not recommended for obstetrical epidural
reserve 0.75% for surgical procedures with prolonged activity

LA
amide
onset of action 5 minutes
duration of action 2-4 hours

LA
amide
onset of < 2 minutes
duration of action 1 hours

LA
amide
ideal for continuous infusion for epidurals during birth
avoid rapid administration of large doses

lidocaine + tetracaine
topical patch
heating mechanism

concern for muscle relaxants

muscle relaxant
non-depolarizing curare agent
first used in arrow poisons

muscle relaxant
non-depolarizing
used by skilled airway management
metabolized by non-oxidative pathways

muscle relaxant
non-depolarizing
diastereomerically pure 15%
metab. by non-oxidative pathway in plasma

muscle relaxant
non-depolarizing
steroidal
especially useful in peds
watch for hepatic failure, increas dose

muscle relaxant
non-depolarizing
steroidal

muscle relaxant
depolarizing
biphasic block
use in extreme caution in CV

muscle relaxant
centrally actin
not used in adjunct with GA
used when unresponsive to oral therapy
constant unfusion pump
don't abruptly discontinue - sphincter clamp
binds to GABA

muscle relaxant
not adjunct for GA
centrally acting
congener of meprobamate
idiosyncratic reaction including allergy

muscle relaxant
not adjunct for GA
centrally acting
urine will be orang or purple-red

muscle relaxant
not adjunct for GA
centrally acting
ineffective in spasm due to CNS disease
similar structurally to TCA's
high protein bound

muscle relaxant
not adjunct for GA
centrally acting
ind - stiff man syndrome
DOC for tetanus

muscle relaxant
non adjunct with GA
centrally acting
possible teratogen
pts watch for signs of liver dysfunction

muscle relaxant
not adjunct for GA
centrally acting
T-1/2 1-2 hrs
uring will be brown, black or green

muscle relaxant
not adjunct for GA
centrally acting
quinine resistant leg cramps
moa - causing analgesia and possess anticholinergic activity

muscle relaxant
not adjunt for GA
centrally acting
caps & tabs - not bioequivalent
alpha 2 adrenergic agonist
use extreme caution in hepatic failure
may cause severe hypotension

muscle relaxant
not adjunct for GA
direct acting
caution of day 1 choking
BBW - hepatotoxic
>35 women monitor serum AST & ALT
oral and IV (management of malignant hyperthermia)

used for the Tx or diagnosis of myasthenia gravis

cholinergic
Tx myasthenia gravis
individualize dosage for less GI disturbances

cholinergic
watch for sulfite sensitivity
comes in atropin combo

cholinergic
reversal of non-depolarizing muscle blockade
contains benzyl alcohol (gasping syndrome)

cholinergic
ind - reduce the symptoms of muscle weakness associated with Eaton lamber
not for myasthenia gravis
dose related fatal bone marrow suppression has occurred

anti-cholinergic
ind - overactive bladder
once daily dosing
SE - heat prostration
CI - uncontrolled narrow-angle glaucoma

anticholinergic
ind - overactive bladder
one tab BID

anticholinergic
ind - overactive bladder
t - 1/2 50hr
appears to prolong QT interval

anti cholinergic
ind - overactive bladder
very selective for the M3 receptor
metab. by 3A4 & 2D6
no effect of QT

anitcholinergic
ind - overactive bladder
metab by 3A4 & 2D6
53% increase in bioavailability
dose dependent on QT

anticholinergic
prodrug of detrol
ind - overactive bladder
no effect on QT